Environmental Epigenomics in Health and Disease: Epigenetics and Disease Origins [1 ed.] 978-3-642-23379-1, 978-3-642-23380-7
There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-o
217 38 31KB
English Pages 302 [308] Year 2013
Table of contents :
Front Matter....Pages i-xv
Front Matter....Pages 1-1
Epigenetics: How Genes and Environment Interact....Pages 3-30
Developmental Epigenomics and Metabolic Disease....Pages 31-50
Sculpting Our Future: Environmental Nudging of the Imprintome....Pages 51-73
Front Matter....Pages 75-75
Complex Phenotypes: Epigenetic Manifestation of Environmental Exposures....Pages 77-97
Epigenetic Effects of Ionizing Radiation....Pages 99-126
The Intersection of Genetics and Epigenetics: Reactivation of Mammalian LINE-1 Retrotransposons by Environmental Injury....Pages 127-160
Front Matter....Pages 161-161
Environmental Impact on Epigenetic Histone Language....Pages 163-187
Chromatin Structure and Gene Expression: Function Follows Form....Pages 189-205
Epigenetics of Pluripotency....Pages 207-223
Front Matter....Pages 225-225
Transgenerational Epigenetic Inheritance in Drosophila....Pages 227-244
Environmental Epigenetics and Epigenetic Transgenerational Inheritance....Pages 245-256
The Nature of Human Transgenerational Responses....Pages 257-271
Back Matter....Pages 273-302
Front Matter....Pages i-xv
Front Matter....Pages 1-1
Epigenetics: How Genes and Environment Interact....Pages 3-30
Developmental Epigenomics and Metabolic Disease....Pages 31-50
Sculpting Our Future: Environmental Nudging of the Imprintome....Pages 51-73
Front Matter....Pages 75-75
Complex Phenotypes: Epigenetic Manifestation of Environmental Exposures....Pages 77-97
Epigenetic Effects of Ionizing Radiation....Pages 99-126
The Intersection of Genetics and Epigenetics: Reactivation of Mammalian LINE-1 Retrotransposons by Environmental Injury....Pages 127-160
Front Matter....Pages 161-161
Environmental Impact on Epigenetic Histone Language....Pages 163-187
Chromatin Structure and Gene Expression: Function Follows Form....Pages 189-205
Epigenetics of Pluripotency....Pages 207-223
Front Matter....Pages 225-225
Transgenerational Epigenetic Inheritance in Drosophila....Pages 227-244
Environmental Epigenetics and Epigenetic Transgenerational Inheritance....Pages 245-256
The Nature of Human Transgenerational Responses....Pages 257-271
Back Matter....Pages 273-302
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