Severe Asthma: Pathogenesis and Clinical Management (Lung Biology in Health and Disease) [2nd ed.] 0824705521, 9780824705527
Providing comprehensive coverage of the pathophysiology, pharmacology, and management of asthma from a multidisciplinary
274 13 2MB
English Pages 673 [706] Year 2001
Table of contents :
CONTENTS......Page 23
INTRODUCTION......Page 11
PREFACE......Page 13
CONTRIBUTORS......Page 17
Asthma as a Progressive Disease......Page 33
Genetic Influences on Asthma Severity......Page 51
Pulmonary Physiology of Severe Asthma in Children and Adults......Page 71
Inflammatory Mediators and Neural Mechanisms in Severe Asthma......Page 99
Role of Airway Remodeling in Severe Asthma......Page 121
Pharmacological Management of Severe Asthma......Page 157
Leukotrienes and Antileukotriene Therapy in Severe Asthma......Page 185
Molecular Mechanisms of Glucocorticoid Action......Page 199
Nocturnal Asthma as a Component of Severe Asthma......Page 227
Complementary and Alternative Therapies for Asthma......Page 253
Gastroesophageal Reflux in Severe Asthma......Page 271
Application of Imaging Procedures in the Diagnosis and Management of Severe Asthma......Page 303
Chronic Infection and Severe Asthma......Page 335
Sleep Disorders in Severe Asthma......Page 355
Allergen-Specific Therapy for Severe Asthma......Page 375
Aspirin, Nonsteroidal Anti-Inflammatory Drugs, and Preservatives as Causes for Severe Asthma......Page 393
Occupational Asthma......Page 421
Clinical Significance of Rhinosinusitis in Severe Asthma and Its Management......Page 451
Monitoring Activity of Severe Asthma......Page 485
Psychosocial Aspects of Severe Asthma in Children......Page 503
Growth Impairment Related to Severe Asthma......Page 537
Steroid-Induced Osteoporosis......Page 565
Management of Severe Asthma......Page 607
Steroid-Resistant Asthma......Page 629
Prevention of Severe Asthma......Page 653
AUTHOR INDEX......Page 669
SUBJECT INDEX......Page 691
CONTENTS......Page 23
INTRODUCTION......Page 11
PREFACE......Page 13
CONTRIBUTORS......Page 17
Asthma as a Progressive Disease......Page 33
Genetic Influences on Asthma Severity......Page 51
Pulmonary Physiology of Severe Asthma in Children and Adults......Page 71
Inflammatory Mediators and Neural Mechanisms in Severe Asthma......Page 99
Role of Airway Remodeling in Severe Asthma......Page 121
Pharmacological Management of Severe Asthma......Page 157
Leukotrienes and Antileukotriene Therapy in Severe Asthma......Page 185
Molecular Mechanisms of Glucocorticoid Action......Page 199
Nocturnal Asthma as a Component of Severe Asthma......Page 227
Complementary and Alternative Therapies for Asthma......Page 253
Gastroesophageal Reflux in Severe Asthma......Page 271
Application of Imaging Procedures in the Diagnosis and Management of Severe Asthma......Page 303
Chronic Infection and Severe Asthma......Page 335
Sleep Disorders in Severe Asthma......Page 355
Allergen-Specific Therapy for Severe Asthma......Page 375
Aspirin, Nonsteroidal Anti-Inflammatory Drugs, and Preservatives as Causes for Severe Asthma......Page 393
Occupational Asthma......Page 421
Clinical Significance of Rhinosinusitis in Severe Asthma and Its Management......Page 451
Monitoring Activity of Severe Asthma......Page 485
Psychosocial Aspects of Severe Asthma in Children......Page 503
Growth Impairment Related to Severe Asthma......Page 537
Steroid-Induced Osteoporosis......Page 565
Management of Severe Asthma......Page 607
Steroid-Resistant Asthma......Page 629
Prevention of Severe Asthma......Page 653
AUTHOR INDEX......Page 669
SUBJECT INDEX......Page 691
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