Recent Advances in the Synthesis of Organic Compounds to Combat Neglected Tropical Diseases 9781608059034

Table of contents :
Cover
Recent Advances in the Synthesis of Organic Compounds to Combat Neglected Tropical Diseases
Copyright
Dedication
Contents
Foreword
Preface
List of Contributors
1. CHAGAS DISEASE. An Overview of Recent Advances in the Search for Synthetic Organic Compounds with Trypanocidal Activity
Abstract
1. Introductuin
2. New Synthetic Molecules
2.1. Naphthoquinones
2.2. Nitrofuranes and Nitrothiophenes
2.3. Metal Complexes
2.4. Nitrogen Heterocycles
2.5. Nitrogenated Open Chain Compounds
2.6. Sugars, Phosphorus Compounds, Phenolic Derivatives
Acknowledgements
Conflict of Interest
References
2. DENGUE FEVER. Recent Advances in the Discovery of Small Organic Molecules for the Prevention and Treatment of Dengue Fever
Abstract
1. Treatment
2. A Medicinal Chemistry Overview of Dengue
2.1. Viral Serine Protease Inhibitors
2.2. Viral Entry Inhibitors
2.3. Inhibitors of RNA Replication
2.4. Other Relevant Compounds
Conclusion
Acknowledgements
Conflict of Interest
References
3. LEISHMANIASIS. An Overview of New Synthetic Antileishmanial Candidates
Abstract
1. Introduction
1.1. Current Drugs in Use
2. New Synthetic Compounds as Antileishmanial Candidates
2.1. Azole Derivatives
2.1.1. Triazole Derivatives
2.1.2. Imidazole Derivatives
2.1.3. Pyrazole Derivatives
2.1.4. Thiadiazole Derivatives
2.1.5. Oxadiazole Derivatives
2.2. Pyridinone and Dihydropyridine Derivatives
2.3. Pyrimidine and Pyrimidone Derivatives
2.4. Quinoline and Isoquinoline Derivatives
2.5. Quinazoline and Quinoxaline Derivatives
2.6. Indole Derivatives
2.7. Purine, Pyrazolopyrimidine, Pyrazolopyridine and Thienopyridine Derivativ
2.8. Benzimidazole, Benzothiazole, Benzoxadiazole and Benzoxazole Derivatives
2.9. Acridine Derivatives
2.10. Coumarine and Pyrane Derivatives
2.11. Azepine Derivatives
2.12. Porfirine Derivatives
2.13. Biguanidines, Amidines and Diamidines
2.14. Sulfonamide Derivatives
2.15. Hydrazone and Hydrazide Derivatives
2.16. Chalcone Derivatives
2.17. Quinone Derivatives
2.18. Alkylphosphocholine and Bisphosphonate Derivatives
2.19. Trioxane Artemisinin Derivatives
2.20. Miscellaneous
Conclusion
Acknowledgements
Conflict of Interest
References
4. LEPROSY. Chasing Potential Antileprotic Compounds
Abstract
1. The Diseare
1.1. The Bacteria
1.1.1. Morphology
1.1.2. Biological Properties
1.1.3. Genomic
1.2. Transmission, Immunology and Classifications
1.3. Natural Immunity and Immunology
1.4. Classifications
1.4.1. Resistance to Leprosy: The Lepromin Test
1.5. Clinical Presentations
1.5.1. Tuberculoid Leprosy (TT)
1.5.2. Lepromatous Leprosy (LL)
1.5.3. Borderline Leprosy
1.6. Reactions
2. Synthetic Studies on Antileprotic Compounds
3. Natural Products Bearing Antileprotic Activity
4. Final Considerations
Acknowledgements
Conflict of Interest
References
5. LYMPHATIC FILARIASIS. Therapeutic Arsenal and Drug Discovery for Lymphatic Filariasis from a Synthetic Point of View
Abstract
1. Epidemiology
2. Biology
3. LF as an Eradicable Disease
4. Chemical Aspects of LF Pharmacotherapy
4.1. Macrolides
4.1.1. Avermectins
4.1.2. Moxidectin
4.2. Diethylcarbamazine (DEC)
4.3. Albendazole
4.4. Anti-Wolbachia Antibiotics
4.5. Suramin
4.6. Other Filaricidal Agents
5. Concluding Remarks
Acknowledgements
Conflict of Interest
References
6. MALARIA. Synthesis of Hybrid Molecules and Inhibitors of Falcipain for Use as Therapeutic Agents in Treatment of Malaria
Abstract
1. Introduction
2. Synthesis of Hybrid Molecules with a Dual Mode of Action
2.1. Endoperoxide-Quinoline Based Hybrids
2.2. Quinoline-Novel Target Based Hybrid
3. Synthesis of Inhibitors of a Cysteine Protease (Falcipain)
3.1. Peptides
3.2. Peptidomimetics
3.3. Chalcones
3.4. Isoquinolines
3.5. Thiosemicarbazones
Acknowledgements
Conflict of Interest
References
7. SCHISTOSOMIASIS. Recent Progresses in Synthesis and Evaluation of Bioactive Compounds with Molluscicidal Activity - Molluscicidal Activity of Synthetic and Natural Products
Abstract
1. Introduction
1.1. Drugs to Control Schistosomiasis
2. Strategies to Combat Schistosomiasis Based Upon Molluscicidal Compounds
2.1. Natural Products
2.2. Synthetic Compounds
3. The Structural Diversity of Bioactive Compounds with Molluscicidal Activity
4. Final Remarks
Acknowledgements
Conflict of Interest
References
8. TUBERCULOSIS. Synthetic Organic Compounds as Potential Antitubercular Drugs: A Review of the Progress Made in the Last Five Years
Abstract
1. Introduction
2. Search Strategy
2.1. ANTI-Mycobacterium Tuberculosis Drugs
Acknowledgements
Conflict of Interest
References
Subject Index