LC-MS in Drug Bioanalysis [1 ed.] 1461438276, 9781461438274
Clinical pharmacology plays an important role in today’s medicine. Due to the high sensitivity, selectivity, and afforda
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English Pages 472 [483] Year 2012
Table of contents :
Front Matter....Pages i-xi
Internal Standards for Quantitative LC-MS Bioanalysis....Pages 1-32
Method Development, Validation, and Sample Analysis for Regulated Quantitative Bioanalysis Using LC-MS/MS....Pages 33-66
Impact of Sampling Paper/Cards on Bioanalytical Quantitation via Dried Blood Spots by Liquid Chromatography-Mass Spectrometry....Pages 67-80
Highly Sensitive Pharmaceutical and Clinical Analysis Using Selective Solid-Phase Extraction Coupled to Microflow Liquid Chromatography and Isotope-Dilution Mass Spectrometry....Pages 81-107
Pitfalls of LC-MS/MS in the Clinical Laboratory....Pages 109-126
Therapeutic Drug Monitoring to Support Clinical Pharmacogenomics....Pages 127-141
Liquid Chromatography-Mass Spectrometry for the Determination of Antidepressants and Some of their Major Metabolites in Human Biological Matrices....Pages 143-175
The Analysis of Antipsychotic Drugs in Human Biosamples by LC-MS....Pages 177-195
Therapeutic Drug Monitoring of Targeted Anticancer Therapy. Tyrosine Kinase Inhibitors and Selective Estrogen Receptor Modulators: A Clinical Pharmacology Laboratory Perspective....Pages 197-250
Applications of Mass Spectrometry in Analyses of Steroid Hormones....Pages 251-286
Liquid Chromatography-Mass Spectrometric Analysis of Tropane Alkaloids in Mammalian Samples: Techniques and Applications....Pages 287-347
Analysis of Illicit Drugs in Human Biological Samples by LC-MS n ....Pages 349-398
Use of Matrix Assisted Laser Desorption/Ionization Imaging Mass Spectrometry (MALDI-IMS) in the Development of Novel Small Molecule Drugs....Pages 399-422
A Planar Integrated Micro-mass Spectrometer....Pages 423-465
Back Matter....Pages 467-469
Front Matter....Pages i-xi
Internal Standards for Quantitative LC-MS Bioanalysis....Pages 1-32
Method Development, Validation, and Sample Analysis for Regulated Quantitative Bioanalysis Using LC-MS/MS....Pages 33-66
Impact of Sampling Paper/Cards on Bioanalytical Quantitation via Dried Blood Spots by Liquid Chromatography-Mass Spectrometry....Pages 67-80
Highly Sensitive Pharmaceutical and Clinical Analysis Using Selective Solid-Phase Extraction Coupled to Microflow Liquid Chromatography and Isotope-Dilution Mass Spectrometry....Pages 81-107
Pitfalls of LC-MS/MS in the Clinical Laboratory....Pages 109-126
Therapeutic Drug Monitoring to Support Clinical Pharmacogenomics....Pages 127-141
Liquid Chromatography-Mass Spectrometry for the Determination of Antidepressants and Some of their Major Metabolites in Human Biological Matrices....Pages 143-175
The Analysis of Antipsychotic Drugs in Human Biosamples by LC-MS....Pages 177-195
Therapeutic Drug Monitoring of Targeted Anticancer Therapy. Tyrosine Kinase Inhibitors and Selective Estrogen Receptor Modulators: A Clinical Pharmacology Laboratory Perspective....Pages 197-250
Applications of Mass Spectrometry in Analyses of Steroid Hormones....Pages 251-286
Liquid Chromatography-Mass Spectrometric Analysis of Tropane Alkaloids in Mammalian Samples: Techniques and Applications....Pages 287-347
Analysis of Illicit Drugs in Human Biological Samples by LC-MS n ....Pages 349-398
Use of Matrix Assisted Laser Desorption/Ionization Imaging Mass Spectrometry (MALDI-IMS) in the Development of Novel Small Molecule Drugs....Pages 399-422
A Planar Integrated Micro-mass Spectrometer....Pages 423-465
Back Matter....Pages 467-469
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- Author / Uploaded
- Aimin Tan
- Nadine Boudreau
- Ann Lévesque (auth.)
- Q. Alan Xu
- Timothy L. Madden (eds.)
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