Gap Junctions: Molecular Basis of Cell Communication in Health and Disease [1 ed.] 0121533492, 9780121533496, 9780080585208

Table of contents :
Content:
Series Editors
Page ii

Edited by
Page iii

Copyright page
Page iv

Contributors
Pages xvii-xxii

Preface
Pages xxiii-xxiv
Camillo Peracchia

Chapter 1: Gap Junction Structure: New Structures and New Insights Original Research Article
Pages 1-22
Gina Sosinsky

Chapter 2: Degradation of Gap Junctions and Connexins Original Research Article
Pages 23-41
James G. Laing, Eric C. Beyer

Chapter 3: Homotypic, Heterotypic, and Heteromeric Gap Junction Channels Original Research Article
Pages 43-60
P.R. Brink, V. Valiunas, G.J. Christ

Chapter 4: Heteromultimeric Gap Junction Channels and Cardiac Disease Original Research Article
Pages 61-93
Sergio Elenes, Alonso P. Moreno

Chapter 5: Ion Permeation Through Connexin Gap Junction Channels: Effects on Conductance and Selectivity Original Research Article
Pages 95-129
Richard D. Veenstra

Chapter 6: Phosphorylation of Connexins: Consequences for Permeability, Conductance, and Kinetics of Gap Junction Channels Original Research Article
Pages 131-144
Habo J. Jongsma, Harold V.M. van Rijen, Brenda R. Kwak, Marc Chanson

Chapter 7: Intercellular Calcium Wave Communication via Gap Junction Dependent and Independent Mechanisms Original Research Article
Pages 145-146,146a,147-148,148a,150-173
Eliana Scemes, Sylvia O. Suadicani, David C. Spray

Chapter 8: Membrane Potential Dependence of Gap Junctions in Vertebrates Original Research Article
Pages 175-188
Luis C. Barrio, Ana Revilla, Juan M. Goméz-Hernandez, Marta de Miguel, Daniel González

Chapter 9: A Reexamination of Calcium Effects on Gap Junctions in Heart Myocytes Original Research Article
Pages 189-206
Bruno Delage, Jean Délèze

Chapter 10: Distinct Behaviors of Chemical and Voltage Sensitive Gates of Gap Junction Channel Original Research Article
Pages 207-221
Feliksas F. Bukauskas, Camillo Peracchia

Chapter 11: A Molecular Model for the Chemical Regulation of Connexin43 Channels: The “Ball-and-Chain” Hypothesis Original Research Article
Pages 223-248
Mario Delmar, Kathleen Stergiopoulos, Nobuo Homma, Guillermo Calero, Gregory Morley, Jose F. Ek-Vitorin, Steven M Taffet

Chapter 12: Mechanistic Differences Between Chemical and Electrical Gating of Gap Junctions Original Research Article
Pages 249-269
I.M. Skerrett, J.F. Smith, B.J. Nicholson

Chapter 13: Behavior of Chemical and Slow Voltage-Sensitive Gates of Connexin Channels: The “Cork” Gating Hypothesis Original Research Article
Pages 271-288,288a,289-295
Camillo Peracchia, Xiao G. Wang, Lillian L. Peracchia

Chapter 14: Molecular Determinants of Voltage Gating of Gap Junctions Formed by Connexin32 and 26 Original Research Article
Pages 297-313
Thaddeus A. Bargiello, Seunghoon Oh, Yi Ri, Priscilla E. Purnick, Vytas K. Verselis

Chapter 15: Regulation of Connexin43 by Tyrosine Protein Kinases Original Research Article
Pages 315-341
Alan F. Lau, Bonnie Warn-Cramer, Rui Lin

Chapter 16: Gating of Gap Junction Channels and Hemichannels in the Lens: A Role in Cataract? Original Research Article
Pages 343-356
Reiner Eckert, Paul Donaldson, JunSheng Lin, Jacqui Bond, Colin Green, Rachelle Merriman-Smith, Mark Tunstall, Joerg Kistler

Chapter 17: Biophysical Properties of Hemi-gap-junctional Channels Expressed in Xenopus Oocytes Original Research Article
Pages 357-367
L. Ebihara, J. Pal

Chapter 18: Properties of Connexin50 Hemichannels Expressed in Xenopus laevis Oocytes Original Research Article
Pages 369-388
Sepehr Eskandari, Guido A. Zampighi

Chapter 19: Gap Junction Communication in Invertebrates: The Innexin Gene Family Original Research Article
Pages 389-422
Pauline Phelan

Chapter 20: Hereditary Human Diseases Caused by Connexin Mutations Original Research Article
Pages 423-459
Charles K. Abrams, Michael V.L. Bennett

Chapter 21: Trafficking and Targeting of Connexin32 Mutations to Gap Junctions in Charcot-Marie-Tooth X-Linked Disease Original Research Article
Pages 461-481
Patricia E.M. Martin, W. Howard Evans

Chapter 22: Molecular Basis of Deafness due to Mutations in the Connexin26 Gene (GJB2) Original Research Article
Pages 483-508
Xavier Estivill, Raquel Rabionet

Chapter 23: “Negative” Physiology: What Connexin-Deficient Mice Reveal about the Functional Roles of Individual Gap Junction Proteins Original Research Article
Pages 509-533
D.C. Spray, T. Kojima, E. Scemes, S.O. Suadicani, Y. Gao, S. Zhao, A. Fort

Chapter 24: Role of Gap Junctions in Cellular Growth Control and Neoplasia: Evidence and Mechanisms Original Research Article
Pages 535-554
Randall J. Ruch

Chapter 25: Gap Junctions in Inflammatory Responses: Connexins, Regulation and Possible Functional Roles Original Research Article
Pages 555-579
Juan C. Sáez, Roberto Araya, María C. Brañes, Miguel Concha, Jorge E. Contreras, Eliseo A. Eugenín, Agustín D. Martinez, Francis Palisson, Manuel A. Sepúlveda

Chapter 26: Cx43 (α1) Gap Junctions in Cardiac Development and Disease Original Research Article
Pages 581-602
Robert G. Gourdie, Cecilia W. Lo

Chapter 27: Gap Junctional Communication in the Failing Heart Original Research Article
Pages 603-623
Walmor C. De Mello

Chapter 28: Gap Junctions Are Specifically Disrupted by Trypanosoma cruzi Infection Original Research Article
Pages 625-634
Regina C.S. Goldenberg, Andrea Gonçalves, Antonio C. Campos de Carvalho

Index
Pages 635-648