Drug Metabolism Enzymes [1 ed.] 0824742931, 9780824742935, 9781420028485

Critical in the elimination of drugs and other xenobiotics from the body, cytochrome P450 has strong bearing on scientif

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Table of contents :
Front Cover......Page 1
Contents......Page 8
Editor's Preface......Page 18
Foreword......Page 20
1. Dioxygen Activation by Cytochromes P450: A Role for Multiple Oxidants in the Oxidation of Substrates......Page 22
2. Application of LC/MS, LC/NMR, NMR and Stable Isotopes in Identifying and Characterizing Metabolites......Page 54
3. Bioactivation......Page 108
4. Chemically Reactive Metabolites in Drug Discovery and Development......Page 168
5. Cytochrome P450 and its Place in Drug Discovery and Development......Page 176
6. Cytochrome P450 in Laboratory Animal Species......Page 200
7. Typical and Atypical Enzyme Kinetics......Page 232
8. Cytochrome P450 Reaction Phenotyping......Page 276
9. Drug-Drug Interactions and the Cytochromes P450......Page 332
10. CYP Gene Induction by Xenobiotics and Drugs......Page 358
11. Cytochrome P450 Pharmacogenetics......Page 396
12. Role of Intestinal Cytochromes P450 in Drug Disposition......Page 442
13. Prediction of Hepatic Clearance in Humans from Experimental Animals and In Vitro Data......Page 474
14. Non-P450 Mediated Oxidative Metabolism of Xenobiotics......Page 504
15. The Role of Sulfotransferases (SULTs) and UDP-GlucuronosyItransferases (UGTs) in Human Drug Clearance and Bioactivation......Page 562
Index......Page 598
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Drug Metabolism Enzymes [1 ed.]
 0824742931, 9780824742935, 9781420028485

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Published in 2003 by CRC Press Taylor & Francis Group 6000 Broken Sound Parkway NW, Suite 300 Boca Raton, FL 33487-2742 © 2003 by Taylor & Francis Group, LLC CRC Press is an imprint of Taylor & Francis Group This book is a joint publication of FontisMedia S.A. and Taylor & Francis Group, LLC No claim to original U.S. Government works Printed in the United States of America on acid-free paper 10 9 8 7 6 5 4 3 2 International Standard Book Number-10: 0-8247-4293-1 (Hardcover) International Standard Book Number-13: 978-0-8247-4293-5 (Hardcover) This book contains information obtained from authentic and highly regarded sources. Reprinted material is quoted with permission, and sources are indicated. A wide variety of references are listed. Reasonable efforts have been made to publish reliable data and information, but the author and the publisher cannot assume responsibility for the validity of all materials or for the consequences of their use. No part of this book may be reprinted, reproduced, transmitted, or utilized in any form by any electronic, mechanical, or other means, now known or hereafter invented, including photocopying, microfilming, and recording, or in any information storage or retrieval system, without written permission from the publishers. Trademark Notice: Product or corporate names may be trademarks or registered trademarks, and are used only for identification and explanation without intent to infringe.

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