Biotechnology [Vol.5a, 2 ed.] 9783527283101, 3527283102, 3527283153
The now completed Second Edition of the Biotechnology book series is the largest source of information in the field cons
270 22 258KB
English Pages 565 Year 1999
Table of contents :
Cover......Page 1
Biotechnology, Second Edition......Page 2
Volume 5a Recombinant Proteins, Monoclonal Antibodies & Therapeutic Genes......Page 4
Copyright......Page 5
Preface......Page 6
Scientific Advisory Board......Page 7
Contents......Page 9
Contributors......Page 11
Structure and Function of Proteins......Page 17
1 Types and Function of Proteins......Page 18
2 Sequence and Structure of Proteins......Page 59
3 Protein Interactions......Page 103
Recombinant Proteins......Page 125
4 In vitro Folding of Inclusion Body Proteins on an Industrial Scale......Page 126
5 Medical Applications of Recombinant Proteins in Humans and Animals......Page 139
6 Enzymes for Industrial Applications......Page 203
Monoclonal Antibodies......Page 231
7 Antibody Engineering and Expression......Page 232
8 Manufacture of Therapeutic Antibodies......Page 258
9 Use of Antibodies for Immunopurification......Page 288
10 Preclinical Testing of Antibodies: Pharmacology, Kinetics and Immunogenicity......Page 302
11 Preclinical Testing of Antibodies: Safety Aspects......Page 316
12 Therapeutic Applications of Monoclonal Antibodies: A Clinical Overview......Page 324
Case Studies......Page 340
13 Antibodies for Sepsis: Some Lessons Learnt......Page 341
14 An Engineered Human Antibody for Chronic Therapy: CDP571......Page 354
15 Antibody Targeted Chemotherapy......Page 365
16 ReoPro Clinical Development: A Case Study......Page 375
Gene Therapy......Page 391
17 Overview of Gene Therapy......Page 392
18 Viral Vectors for Gene Therapy......Page 403
l9 Non-Viral Vectors for Gene Therapy......Page 434
20 Issues of Large-Scale Plasmid DNA Manufacturing......Page 449
21 Gene Therapy for HIV Infection......Page 476
Regulatory and Economic Aspects......Page 498
22 Regulation of Antibodies and Recombinant Proteins......Page 499
23 Regulation of Human Gene Therapy......Page 521
24 Economic Considerations......Page 534
Index......Page 546
Cover......Page 1
Biotechnology, Second Edition......Page 2
Volume 5a Recombinant Proteins, Monoclonal Antibodies & Therapeutic Genes......Page 4
Copyright......Page 5
Preface......Page 6
Scientific Advisory Board......Page 7
Contents......Page 9
Contributors......Page 11
Structure and Function of Proteins......Page 17
1 Types and Function of Proteins......Page 18
2 Sequence and Structure of Proteins......Page 59
3 Protein Interactions......Page 103
Recombinant Proteins......Page 125
4 In vitro Folding of Inclusion Body Proteins on an Industrial Scale......Page 126
5 Medical Applications of Recombinant Proteins in Humans and Animals......Page 139
6 Enzymes for Industrial Applications......Page 203
Monoclonal Antibodies......Page 231
7 Antibody Engineering and Expression......Page 232
8 Manufacture of Therapeutic Antibodies......Page 258
9 Use of Antibodies for Immunopurification......Page 288
10 Preclinical Testing of Antibodies: Pharmacology, Kinetics and Immunogenicity......Page 302
11 Preclinical Testing of Antibodies: Safety Aspects......Page 316
12 Therapeutic Applications of Monoclonal Antibodies: A Clinical Overview......Page 324
Case Studies......Page 340
13 Antibodies for Sepsis: Some Lessons Learnt......Page 341
14 An Engineered Human Antibody for Chronic Therapy: CDP571......Page 354
15 Antibody Targeted Chemotherapy......Page 365
16 ReoPro Clinical Development: A Case Study......Page 375
Gene Therapy......Page 391
17 Overview of Gene Therapy......Page 392
18 Viral Vectors for Gene Therapy......Page 403
l9 Non-Viral Vectors for Gene Therapy......Page 434
20 Issues of Large-Scale Plasmid DNA Manufacturing......Page 449
21 Gene Therapy for HIV Infection......Page 476
Regulatory and Economic Aspects......Page 498
22 Regulation of Antibodies and Recombinant Proteins......Page 499
23 Regulation of Human Gene Therapy......Page 521
24 Economic Considerations......Page 534
Index......Page 546
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- Hans-Jürgen Rehm
- Gerald Reed
- Alfred Pühler
- Peter Stadler
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