Atlas of the Neonatal Rat Brain [1 ed.] 1439840121, 9781439840122

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Atlas of the

NEONATAL RAT BRAIN

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Atlas of the

NEONATAL RAT BRAIN Renuka Ramachandra Thyagarajan Subramanian

Boca Raton London New York

CRC Press is an imprint of the Taylor & Francis Group, an informa business

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CRC Press Taylor & Francis Group 6000 Broken Sound Parkway NW, Suite 300 Boca Raton, FL 33487-2742 © 2011 by Taylor and Francis Group, LLC CRC Press is an imprint of Taylor & Francis Group, an Informa business No claim to original U.S. Government works Printed in the United States of America on acid-free paper 10 9 8 7 6 5 4 3 2 1 International Standard Book Number: 978-1-4398-4012-2 (Hardback) This book contains information obtained from authentic and highly regarded sources. Reasonable efforts have been made to publish reliable data and information, but the author and publisher cannot assume responsibility for the validity of all materials or the consequences of their use. The authors and publishers have attempted to trace the copyright holders of all material reproduced in this publication and apologize to copyright holders if permission to publish in this form has not been obtained. If any copyright material has not been acknowledged please write and let us know so we may rectify in any future reprint. Except as permitted under U.S. Copyright Law, no part of this book may be reprinted, reproduced, transmitted, or utilized in any form by any electronic, mechanical, or other means, now known or hereafter invented, including photocopying, microfilming, and recording, or in any information storage or retrieval system, without written permission from the publishers. For permission to photocopy or use material electronically from this work, please access www.copyright.com (http://www.copyright.com/) or contact the Copyright Clearance Center, Inc. (CCC), 222 Rosewood Drive, Danvers, MA 01923, 978-750-8400. CCC is a not-for-profit organization that provides licenses and registration for a variety of users. For organizations that have been granted a photocopy license by the CCC, a separate system of payment has been arranged. Trademark Notice: Product or corporate names may be trademarks or registered trademarks, and are used only for identification and explanation without intent to infringe. Visit the Taylor & Francis Web site at http://www.taylorandfrancis.com and the CRC Press Web site at http://www.crcpress.com

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Dedication

We dedicate this scientific work to our parents who inspired us to follow our interests and provided unwavering support to us during all our struggles and successes.

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Contents

Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix Acknowledgments . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xi About the Authors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xiii Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xv Abbreviations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xix References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xxiii

Section Iâ•… P-1 Brain Coronal Plates (Figures 1 through 30) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Sagittal Plates (Figures 31 through 44) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33

Section IIâ•… P-7 Brain Coronal Plates (Figures 45 through 71) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49 Sagittal Plates (Figures 72 through 95) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 76

Section IIIâ•… P-14 Brain Coronal Plates (Figures 96 through 136) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 103 Sagittal Plates (Figures 137 through 157) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 144

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Preface

T

he rat brain develops enormously after birth and the changes are very rapid. We have attempted to prepare a photographic atlas representing the neonatal rat brain at postnatal (P) days P-1, P-7, and P-14. This atlas illustrates the main anatomical features at these three ages. It will serve the needs of researchers and students who are interested in postnatal development, slice cultures, developmental disorders, neuroanatomy, neuropharmacology, neurobiochemistry, and neuropathology of rats. We hope that this atlas will provide a template for comparative studies with other species and numerous animal models of brain pathology in rats.

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Acknowledgments

W

e are grateful to the following individuals for making this atlas work possible through their moral, emotional, technical, and scientific support: David Good, Keith Elmslie, Kala Venkiteswaran, Sriram S. Shanmugavelandy, Christopher Lieu, Anand Rao, Mathew Berk, Timothy Gilmour, and Barbara Norwitz. We also acknowledge financial support for this work from research grants to Thyagarajan Subramanian from the National Institutes of Health (NS42402), Commonwealth of Pennsylvania Tobacco Settlement Biomedical Research Fund, and the Penn State University Brain Repair Research Fund. We also thank the U.S. Department of Health for the Physician Scientist Research Award.

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About the Authors

Renuka Ramachandra, is a postdoctoral researcher at the AT Still University in Kirksville, Missouri. She received her PhD degree in neurophysiology from India and her initial postdoctoral training at the National Brain Research Centre in India, a premier neuroscience institute. Dr. Ramachandra worked on the effect of barrel cortex lesions in rats and on the effects of drugs on the developing rat brain. She also worked as a research scientist in the embryonic stem cell group at Reliance Life Sciences, Mumbai, India, where she differentiated human embryonic stem cells into oligodendrocytes for spinal cord injury treatment. She went on to use her skills and knowledge of basic electrophysiology, brain anatomy, and histological techniques to develop an in vitro basal ganglia slice culture model in the Department of Neurology at Penn State College of Medicine. This model is used to study in vitro cell transplantation. During the development of this model, she recognized the need for a neonatal rat brain atlas. Dr. Ramachandra created this atlas for her project and decided to publish it so that it would be available to all neuroscientists and students who need one. Thyagarajan Subramanian is a professor of neurology and neural and behavioral sciences at Penn State University Hershey Medical Center in Hershey, Pennsylvania. Dr. Subramanian received his initial medical training from Calicut Medical College in Calicut, India and his graduate training in developmental neurobiology and neural cell transplantation under the guidance of Dr. R. D. Lund at the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. He completed his neurology residency at the University of Pittsburgh followed by fellowship training in neurological research and movement disorders at Emory University in Atlanta, Georgia under the guidance of Drs. Mahlon R. DeLong, Ray L. Watts, and Roy A. E. Bakay. Dr. Subramanian’s research interests are in developmental neurobiology, basal ganglia physiology, cell transplantation, gene therapy, and experimental neurotherapeutics. Using a variety of animal models, cell and tissue culture techniques, in vivo electrophysiology, and detailed histology, Dr. Subramanian and co-workers have described several novel findings in central nervous system (CNS) response to transplantation. Among his major scientific contributions are his work on creating an MRI based brain atlas of the Rhesus monkey, description of the effects of immunomodulation on host responses to CNS xenografting, and the description of the use of retinal pigment epithelial cell grafts for CNS repair. Dr. Subramanian has directed the medical neuroscience course for medical and graduate students and trained numerous medical students, as well as neurology, neurosurgery, physiatry, psychiatry, and geriatric residents. He has served as the education committee chair of the American Society for Neural Therapy and Repair (ASNTR) and has trained numerous scientists and physicians who now work as independent investigators in many institutions all over the world. xiii

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Introduction

R

odents have frequently been used to model a number of neurological disorders. The neonatal rat in particular has been used in many developmental studies and extensively for preparing slice culture models that permit the study of interactions among different regions of the brain during development. Neonatal rats have also been used as models for neurotoxicological screening and mechanistic studies (Becker and Liu, 2006; Noraberg, 2004). During our attempts to develop a neonatal rat brain slice culture model of basal ganglia development, we realized that there was no published neonatal rat brain atlas. This took us by surprise as we knew of quite a few adult rat brain atlases. To remedy this situation, we developed this atlas showing representative development of the rat brain between postnatal day 1 (P-1) and postnatal day 14 (P-14). A number of animals from each litter were euthanized on the designated postnatal dates and the brains were sectioned, stained, photographed, and annotated to prepare this atlas. This atlas is an effort to provide a guide to the neonatal rat brain. It contains a comprehensive set of histological images of the newborn rat brain from P-1, P-7, and P-14. Although we prepared brain sections for all the ages from P-1 to P-14, we have chosen to present these three ages as representative to provide a template of developmental maturation of the neonatal rat brain at various stages. Further, the inclusion of every age between P-1 and P-14 would needlessly add pages to this atlas without adding value. Additional images will be made available as electronic resources for individuals who seek images not represented in this volume. P-0 was covered earlier in The Atlas of the Developing Rat Nervous System€(Paxinos et al., 1994), so we started at P-1, proceeded to P-7 (the midpoint in neonatal development), and concluded at P-14. This atlas contains both coronal and sagittal sections for all the three age groups. The P-1 section contains 30 coronal plates and 14 sagittal plates; P-7 includes 27 coronal plates and 24 sagittal plates. The final P-14 section shows 41 coronal plates and 21 sagittal plates. Each set consists of contiguous sections from individual animals with no substitutions or omissions. The sections were prepared carefully to ensure that their orientations were maintained and were consistently of the highest quality. The selections were based on the structural variability represented. Care was taken to minimize tears and distortions. Fixation and staining cause minimal amounts of shrinkage and damage to tissues. However, we feel that the structural details are well preserved. This atlas has certain unique features. The sections are Nissl stained with cresyl violet—the most common staining technique used in the neurosciences. Future editions will include specific immunostains and special stains in the same format as these Nissl stains. The photomicrographs achieve high resolution and clarity. The structures are directly labeled on the images, making it easier for readers to correlate data. The electronic version will allow labels to be removed so the atlas can be used as a teaching tool. xv

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xvi

Atlas of the Neonatal Rat Brain

Animal Preparation Sprague-Dawley rat pups were used for this work. Pregnant dams from Charles River Laboratories (Wilmington, MA) were received on day 13.5 of gestation and housed in standard laboratory conditions, with 12-hour dark and light cycles and administration of food and water ad libitum. All procedures complied with guidelines issued by the National Institutes of Health and were approved by Penn State University’s Institutional Animal Care and Welfare Committee. After birth, rat pups ranging in age from P-1 to P-14 were sacrificed at the same time every day. The sexes of the newborns were not taken into consideration. The neonates were decapitated and the brains were removed carefully and postfixed in 4% paraformaldehyde for 3 to 4 days. This allowed preservation of the brain structures and made it easier to isolate the brains from the delicate skulls. The brains were then cryoprotected in 15% sucrose in phosphate buffered saline (PBS) and then in 30% sucrose in PBS. The brains were positioned and frozen on sucrose blocks made on the base of a sliding microtome that was then used to cut the brains at 50-µm thickness for both coronal and sagittal views. For sagittal sections, each brain was cut along the midline carefully and placed with the midline facing the block. Care was taken to retain and mount every section cut. We noted all missing sections so that we could calculate the correct distance from the midline for the sagittal sections.

Section Processing Every section was mounted on polylysine-coated slides, air dried, and stained for Nissl bodies using cresyl violet. In short, the slides with the sections were passed through the solutions for 3 minutes each in the following order except where noted: 100% ethanol, 100% ethanol, 95% ethanol, 75% ethanol, water (single dip), cresyl violet (3 to 4 minutes), water, 75% ethanol, 95% ethanol, 100% ethanol, 100% ethanol, and xylene. The slides were cover slipped using DPX mounting media and left to dry for 2 days before image capture. To make 500 ml of 0.5% cresyl violet (pH about 3.9), we mixed 2.5 g cresyl echt violet, 300 mL water, 30 mL 0.1 M sodium acetate (13.6 g granular sodium acetate in 92 mL water), and 170 mL 1.0 M acetic acid (29 mL glacial acetic acid added to 471 mL water). This solution was mixed at least 7 days on a magnetic stirrer and then filtered.

Imaging Using Neurolucida software (Version 8, MBF Biosciences), photomicrographs of all the serial sections were captured. We used the virtual slice feature of Neurolucida that allowed us to capture the images at 4× magnification in smaller blocks and finally merge them to yield a holistic image of an entire section. In digital format, the images can be zoomed in without losing much of the detail. The images were post processed in Adobe Photoshop to clear up the background. No changes were made to the actual photomicrographic images captured.

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Introduction

xvii

Labeling The images were labeled based on the nomenclature used by Paxinos, with some modifications to suit the need of the atlas. For the P-1 rat brain, we labeled most structures using The Atlas of the Developing Rat Nervous System (Paxinos et al., 1994). Because the P-7 and P-14 brain structures are similar to those of adult rat brains, we followed the nomenclature of The Rat Brain in Stereotaxic Coordinates (Paxinos et al., 1998). The labeling of the respective structures was done on the actual photographic images rather than on the classic line diagrams that most atlases utilize. This allows the user to correlate the structures and their names easily. We decided not to demarcate the areas on the brain as the brain is a very plastic structure and the areas could not be distinguished from each other easily. The major parts of the brain were labeled via Adobe Photoshop without the inclusion of minor details. We used cresyl violet stain to identify the structures. This posed limitations on identifying some of the smaller nuclei that required special staining. Most of the structures were identified based on the proximity to the surrounding structures and outstanding landmarks; for example, striatum was identified based on its patchy matrix and close proximity to the corpus callosum. The most difficult structures to identify were the thalamic nuclei in the P-1 brains. We restricted our labeling to major nuclei only to avoid confusion. Since the brain develops very quickly in the first few days after birth, it is very difficult to demarcate the developing nuclei without in-depth knowledge of that area of research. The other structure that posed certain limitations in labeling was the cerebellum of the P-1 brain. The lobules are very different from those of the adult brain. We tried to keep most of the sagittal brain sections intact. However, we encountered a few sections in which the cerebellum could not be kept intact with the rest of the brain. The distances between adjacent plates of the sagittal sections were estimated from the midline using the section thickness; the midline was considered the absolute zero. This photographic atlas can assist neuroscientists and students to identify and understand the developing rat brain structure. However, it does not cover stereotaxic coordinates.

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Abbreviations

Numbers 1 through 10 aca Acb AcbC AcbSh AICtx Alv AM amy Amy AICtx AO APit apons APT AT AuCtx AV Bamy BLA CA1 CA2 CA3 cc Cer cer Cernu CG CgCtx CM Cop Cp CPu Crus1 Crus2 Ctx Cu D3V DG Dhippo DLG DR DTg E Ec Ent EPI

Cerebellar lobules Anterior commissure Accumbens nucleus Accumbens nucleus core Accumbens nucleus shell Agranular insular cortex Alveus of hippocampus Anteromedial thalamus Amygdala Amygdaloid nuclei Agranular insular cortex Anterior olfactory bulb Anterior pituitary gland Anterior pons Anterorpretectal nuclei Anterior thalamus Auditory cortex Anteroventral thalamus Basal amygdala Basolateral amygdala CA1 field of hippocampus CA2 field of hippocampus CA3 field of hippocampus Corpus callosum Cerebellar peduncle Cerebellum Cerebellar nuclei Central gray matter Cingulate cortex Central medial thalamic nuclei Copula of pyramis Caudate peduncle Caudate putamen Crus 1 of ansiform lobule Crus 2 of ansiform lobule Cortex Cuneate nucleus Dorsal third ventricle Dentate gyrus Dorsal hippocampal formation Dorsolateral geniculate nuclei Dorsal raphe nuclei Dorsal tegmental nuclei Ependyma and subependymal layer External capsule Entorhinal cortex External plexiform layer, olfactory bulb

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xx

Atlas of the Neonatal Rat Brain f fi fmi fmj FrCtx gcc GI CN GP GrO hc Hf Hfor Hypo IAD IC Ic InsCtx IPL Lamy Lat LD LDVL Lent LGP LPAG LPLR LPM LS LT LTh LV MCtx MD MDTh Med MEnt MEPD MGD MGN MGV Mret MT neoCtx obn OcCtx Opt Orb OV PAG Pal pcf Pi Pir Pit PLCtx Plf PM

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Fornix Fimbria of hippocampus Forceps minor of corpus callosum Forceps major of corpus callosum Frontal cortex Genu of corpus callosum Glomerular layer, olfactory bulb Geniculate nucleus Globus pallidus Granular cell layer, olfactory bulb Hippocampal commissure Hippocampal fissure Hippocampal formation Hypothalamus Interanterodorsal thalamic nuclei Inferior colliculus Internal capsule Insular cortex Internal plexiform layer, olfactory bulb Lateral amygdala Lateral cerebellar nuclei Laterodorsal thalamic nuclei Laterodorsoventral thalamus Lateral entorhinal cortex Lateral globus pallidus Lateral periaqueductal gray matter Lateroposterior thalamic nuclei Lateroposteromedial thalamic nuclei Lateral septal nuclei Lateral thalamus Lateral thalamic nucleus Lateral ventricle Motor cortex Mediodorsal thalamic nuclei Mediodorsal thalamus Medulla Medial entorhinal cortex Medial amygdala nuclei Medial geniculate nuclei, dorsal Medial geniculate nuclei Medial geniculate nuclei, ventral Medullary reticular formation Medial thalamus Neocortex Olfactory bulb neuroepithelium Occipital cortex Optic tract Orbital cortex Olfactory ventricle Periaqueductal gray matter Pallidum Precommissural fornix Pineal gland Piriform cortex Pituitary gland Prelimbic cortex Posterolateral fissure Paramedian lobule

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Abbreviations Pn Po PrCtx PrS PtACtx PTg PTh RsCtx S SC SCtx Sim SN SNc SNr Spn STn Sub SubG Th VCtx Ve VH Vhippo VL VM VO VP VPL VPM VT VTh ZI

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xxi

Pontine nuclei Posterior thalamic nuclei Parietal cortex Presubiculum Parietal association cortex Posterior tegmental nuclei Posterior thalamus Retrospenial cortex Subiculum Superior colliculus Somatosensory cortex Simple lobule Substantia nigra Substantia nigra compacta Substantia nigra reticulata Spinal nuclei Subthalamic nuclei Submedial thalamic nucleus Subgeniculate nucleus Thalamus Visual cortex Vestibular nuclei Ventral hypothalamus Ventral hippocampal formation Ventrolateral thalamic nuclei Ventromedial thalamus Ventral orbital cortex Ventral pallidum Ventroposterolateral thalamic nuclei Ventroposteromedial thalamic nuclei Ventral thalamus Ventral thalamic nucleus Zona incerta

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References

Altman, J. and Bayer, S. (1995). The Atlas of Prenatal Rat Brain Development. Boca Raton, FL: CRC Press. Becker, S. and Liu, X. (2006). Evaluation of the utility of brain slice methods to study brain penetration. Drug Metab Dispos 34: 855–861. Noraberg, J. (2004). Organotypic brain slice cultures: An efficient and reliable method for neurotoxicological screening and mechanistic studies. Altern Lab Anim 32: 329–337. Paxinos, G. and Watson, C. (1998). The Rat Brain in Stereotaxic Coordinates. Fourth Edition. San Diego: Elsevier Academic Press. Paxinos, G., Ashwell, K.W.S., and Tork, I. (1994). The Atlas of the Developing Rat Nervous System. San Diego: Elsevier Academic Press.

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Section I

P-1 Brain

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Coronal Plates

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Coronal Plates

Figure 1 P-1, c1 EPI = External plexiform layer, olfactory bulb GI = Glomerular layer, olfactory bulb Obn = Olfactory bulb neuroepithelium OV = Olfactory ventricle

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Atlas of the Neonatal Rat Brain

Figure 2 P-1, c2 AICtx = Agranular insular cortex AO = Anterior olfactory bulb CgCtx = Cingulate cortex FrCtx = Frontal cortex Orb = Orbital cortex OV= Olfactory ventricle

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Coronal Plates

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Figure 3 P-1, c3 AICtx = Agranular insular cortex AO = Anterior olfactory bulb CgCtx = Cingulate cortex FrCtx = Frontal cortex Orb = Orbital cortex OV = Olfactory ventricle

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Atlas of the Neonatal Rat Brain

Figure 4 P-1, c4 AICtx = Agranular insular cortex CgCtx = Cingulate cortex fmi = Forceps minor of corpus callosum FrCtx = Frontal cortex Pir = Piriform cortex PrCtx = Parietal cortex

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Coronal Plates

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Figure 5 P-1, c5 aca = Anterior commissure Acb = Accumbens nucleus CgCtx = Cingulate cortex CPu = Caudate putamen ec = external capsule FrCtx = Frontal cortex LS = Lateral septal nuclei LV = Lateral ventricle pir = Piriform cortex PrCtx = Parietal cortex

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Atlas of the Neonatal Rat Brain

Figure 6 P-1, c6 aca = Anterior commissure Acb = Accumbens nucleus CgCtx = Cingulate cortex CPu = Caudate putamen ec = external capsule FrCtx = Frontal cortex LS = Lateral septal nuclei LV = Lateral ventricle Pir = Piriform cortex PrCtx = Parietal cortex

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Coronal Plates

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Figure 7 P-1, c7 aca = Anterior commissure Acb = Accumbens nucleus CgCtx = Cingulate cortex CPu = Caudate putamen ec = external capsule FrCtx = Frontal cortex gcc = Genu of corpus callosum LS = Lateral septal nuclei LV = Lateral ventricle pir = Piriform cortex PrCtx = Parietal cortex

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Atlas of the Neonatal Rat Brain

Figure 8 P-1, c8 aca = Anterior commissure Acb = Accumbens nucleus AcbSh = Accumbens nucleus shell CgCtx = Cingulate cortex CPu = Caudate putamen ec = external capsule FrCtx = Frontal cortex gcc = Genu of corpus callosum LS = Lateral septal nuclei LV = Lateral ventricle pir = Piriform cortex PrCtx = Parietal cortex

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Coronal Plates

Figure 9 P-1, c9 aca = Anterior commissure Acb = Accumbens nucleus AcbSh = Accumbens nucleus shell CgCtx = Cingulate cortex CPu = Caudate putamen ec = external capsule

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FrCtx = Frontal cortex gcc = Genu of corpus callosum LS = Lateral septal nuclei LV = Lateral ventricle pir = Piriform cortex PrCtx = Parietal cortex

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Atlas of the Neonatal Rat Brain

Figure 10 P-1, c10 aca = Anterior commissure CA3 = CA3 field of hippocampus CgCtx = Cingulate cortex CPu = Caudate putamen ec = external capsule FrCtx = Frontal cortex gcc = Genu of corpus callosum

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GP = Globus pallidus hc = Hippocampal commissure InsCtx = Insular cortex LS = Lateral septal nuclei LV = Lateral ventricle pir = Piriform cortex PrCtx = Parietal cortex

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Coronal Plates

Figure 11 P-1, c11 aca = Anterior commissure CA3 = CA3 field of hippocampus CPu- = Caudate putamen DG = Dentate gyrus ec = external capsule f = Fornix FrCtx = Frontal cortex

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13

cc = Corpus callosum GP = Globus pallidus insCtx = Insular cortex LS = Lateral septal nuclei LV = Lateral ventricle pir = Piriform cortex PrCtx = Parietal cortex

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Atlas of the Neonatal Rat Brain

Figure 12 P-1, c12 Amy = Amygdaloid nuclei ATh = Anterior thalamus CA1 = CA1 field of hippocampus CA3 = CA3 field of hippocampus cc = Corpus callosum CPu = Caudate putamen DG = Dentate gyrus

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ec = external capsule f = Fornix FrCtx = Frontal cortex GP = Globus pallidus LV = Lateral ventricle pir = Piriform cortex PrCtx = Parietal cortex

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Coronal Plates

Figure 13 P-1, c13 Amy = Amygdaloid nuclei ATh = Anterior thalamus CA1 = CA1 field of hippocampus CA3 = CA3 field of hippocampus CPu = Caudate putamen

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DG = Dentate gyrus F = Fornix FrCtx = Frontal cortex pir = Piriform cortex PrCtx = Parietal cortex

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Atlas of the Neonatal Rat Brain

Figure 14 P-1, c14 Amy = Amygdaloid nuclei CA1 = CA1 field of hippocampus CA3 = CA3 field of hippocampus CPu = Caudate putamen DG = Dentate gyrus ec = external capsule F = Fornix FrCtx = Frontal cortex

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GP = Globus pallidus Hypo = Hypothalamus LTh = Lateral thalamus LV = Lateral ventricle MDTh = Mediodorsal thalamus pir = Piriform cortex PrCtx = Parietal cortex VTh = Ventral thalamus

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Coronal Plates

Figure 15 P-1, c15 Amy = Amygdaloid nuclei CA1 = CA1 field of hippocampus CA3 = CA3 field of hippocampus DG = Dentate gyrus FrCtx = Frontal cortex Hypo = Hypothalamus LTh = Lateral thalamus

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LV = Lateral ventricle MDTh = Mediodorsal thalamus pir = Piriform cortex PrCtx = Parietal cortex VTh = Ventral thalamus ZI = Zona incerta

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Atlas of the Neonatal Rat Brain

Figure 16 P-1, c16 Amy = Amygdaloid nuclei CA1 = CA1 field of hippocampus CA3 = CA3 field of hippocampus DG = Dentate gyrus FrCtx = Frontal cortex LTh = Lateral thalamus MDTh = Mediodorsal thalamus pir = Piriform cortex OcCtx = Occipital cortex

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Coronal Plates

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Figure 17 P-1, c17 Amy = Amygdaloid nuclei CA1 = CA1 field of hippocampus CA3 = CA3 field of hippocampus DG = Dentate gyrus OcCtx = Occipital cortex Pi = Pineal gland SC = Superior colliculus SNr = Substantia nigra reticulata ZI = Zona incerta

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Atlas of the Neonatal Rat Brain

Figure 18 P-1, c18 Amy = Amygdaloid nuclei CA1 = CA1 field of hippocampus CA3 = CA3 field of hippocampus cp = Caudate peduncle DG = Dentate gyrus Ent = Entorhinal cortex OcCtx = Occipital cortex SC = Superior colliculus SNr = Substantia nigra reticulata ZI = Zona incerta

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Coronal Plates

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Figure 19 P-1, c19 CG = Central gray matter DR = Dorsal raphe nuclei Pn = Pontine nuclei SC = Superior colliculus

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Atlas of the Neonatal Rat Brain

Figure 20 P-1, c20 CG = Central gray matter SC = Superior colliculus

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Coronal Plates

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Figure 21 P-1, c21 PAG = Periaqueductal gray matter SC = Superior colliculus

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Atlas of the Neonatal Rat Brain

Figure 22 P-1, c22 DTg = Dorsal tegmental nuclei SC = Superior colliculus

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Coronal Plates

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Figure 23 P-1, c22 IC = Inferior colliculus Med = Medulla

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Atlas of the Neonatal Rat Brain

Figure 24 P-1, c24 Cer = Cerebellar peduncle CG = Central gray matter DTg = Dorsal tegmental nuclei PTg = Posterior tegmental nuclei IC = Inferior colliculus SC = Superior colliculus

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Coronal Plates

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Figure 25 P-1, c25 Cernu = Cerebellar nuclei IC = Inferior colliculus Med = Medulla Ve = Vestibular nucleus

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Atlas of the Neonatal Rat Brain

Figure 26 P-1, c26 Cernu = Cerebellar nuclei IC = Inferior colliculus Med = Medulla Ve = Vestibular nuclei

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Coronal Plates

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Figure 27 P-1, c27 Cernu = Cerebellar nuclei Med = Medulla Ve = Vestibular nuclei

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30

Atlas of the Neonatal Rat Brain

Figure 28 P-1, c28 Cernu = Cerebellar nuclei Med = Medulla Ve = Vestibular nuclei

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10/26/10 4:31:33 PM

Coronal Plates

31

Figure 29 P-1, c29 Cernu = Cerebellar nuclei Med = Medulla

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10/26/10 4:31:34 PM

32

Atlas of the Neonatal Rat Brain

Figure 30 P-1, c30 Mret = Medullary reticular formation

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10/26/10 4:31:35 PM

Sagittal Plates

33

Sagittal Plates

Figure 31 P-1, s1 AO = Anterior olfactory bulb cc = Corpus callosum Cer = Cerebellar peduncle CgCtx = Cingulate cortex EPI = External plexiform layer, olfactory bulb GI = Glomerular layer, olfactory bulb Hypo = Hypothalamus

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IC = Inferior colliculus PAG = Periaqueductal gray matter Pi = Pineal gland Med = Medulla SC = Superior colliculus Th = Thalamus

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34

Atlas of the Neonatal Rat Brain

Figure 32 P-1, -s2 AO = Anterior olfactory bulb cc = Corpus callosum CgCtx = Cingulate cortex EPI = External plexiform layer, olfactory bulb GI = Glomerular layer, olfactory bulb Hypo = Hypothalamus IC = Inferior colliculus Med = Medulla OV = Olfactory ventricle PAG = Periaqueductal gray matter Pi = Pineal gland Pit = Pituitary gland SC = Superior colliculus Th = Thalamus

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10/26/10 4:31:36 PM

Sagittal Plates

Figure 33 P-1, s3 Acb = Accumbens nucleus AO = Anterior olfactory bulb cer = Cerebellum CPu = Caudate putamen DG = Dentate gyrus EPI = External plexiform layer, olfactory bulb FrCtx = Frontal cortex

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35

Hypo = Hypothalamus Med = Medulla OV = Olfactory ventricle Pit = Pituitary gland SC = Superior colliculus Th = Thalamus

10/26/10 4:31:36 PM

36

Atlas of the Neonatal Rat Brain

Figure 34 P-1, s4 Acb = Accumbens nucleus AO = Anterior olfactory bulb cc = Corpus callosum cer = Cerebellum CPu = Caudate putamen EPI = External plexiform layer, olfactory bulb FrCtx = Frontal cortex

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GI = Glomerular layer, olfactory bulb Hypo = Hypothalamus IC = Inferior colliculus Pit = Pituitary gland Med = Medulla SC = Superior colliculus Th = Thalamus

10/26/10 4:31:37 PM

Sagittal Plates

Figure 35 P-1, s5 Acb = Accumbens nucleus ATh = Anterior thalamus AO = Anterior olfactory bulb apons = Anterior pons CA1 = CA1 field of hippocampus CA3 = CA3 field of hippocampus cc = Corpus callosum CPu = Caudate putamen DG = Dentate gyrus FrCtx = Frontal cortex

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37

GP = Globus pallidus Hypo = Hypothalamus IC = Inferior colliculus OV = Olfactory ventricle Pit = Pituitary gland PTh = Posterior thalamus Med = Medulla SC = Superior colliculus Th = Thalamus

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38

Atlas of the Neonatal Rat Brain

Figure 36 P-1, s6 Acb = Accumbens nucleus AO = Anterior olfactory bulb ATh = Anterior thalamus CA1 = CA1 field of hippocampus CA3 = CA3 field of hippocampus cc = Corpus callosum cer = Cerebellum CPu = Caudate putamen DG = Dentate gyrus

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FrCtx = Frontal cortex Hypo = Hypothalamus IC = Inferior colliculus Med = Medulla OV = Olfactory ventricle Pit = Pituitary gland PTh = Posterior thalamus SC = Superior colliculus Th = Thalamus

10/26/10 4:31:38 PM

Sagittal Plates

Figure 37 P-1, s7 Acb = Accumbens nucleus ATh = Anterior thalamus CA1 = CA1 field of hippocampus CA3 = CA3 field of hippocampus cc = Corpus callosum cer = Cerebellum CPu = Caudate putamen DG = Dentate gyrus FrCtx = Frontal cortex

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39

Hypo = Hypothalamus IC = Inferior colliculus Ic = Internal capsule Med = Medulla OV = Olfactory ventricle Pit = Pituitary gland PTh = Posterior thalamus SC = Superior colliculus Th = Thalamus

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40

Atlas of the Neonatal Rat Brain

Figure 38 P-1, s8 Acb = Accumbens nucleus ATh = Anterior thalamus CA1 = CA1 field of hippocampus CA3 = CA3 field of hippocampus cc = Corpus callosum cer = Cerebellum CPu = Caudate putamen DG = Dentate gyrus Hypo = Hypothalamus IC = Inferior colliculus

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Ic = Internal capsule Med = Medulla Pal = Pallidum Pit = Pituitary gland PTh = Posterior thalamus SC = Superior colliculus STn = Subthalamic nuclei Th = Thalamus ZI = Zona incerta

10/26/10 4:31:39 PM

Sagittal Plates

Figure 39 P-1, s9 Amy = Amygdaloid nuclei ATh = Anterior thalamus Acb = Accumbens nuclei CA1 = CA1 field of hippocampus CA3 = CA3 field of hippocampus cc = Corpus callosum cer = Cerebellum CPu = Caudate putamen

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41

DG = Dentate gyrus Hypo = Hypothalamus GP = Globus pallidus Ic = Internal capsule IC = Inferior colliculus pal = Pallidum PTh = Posterior thalamus

10/26/10 4:31:40 PM

42

Atlas of the Neonatal Rat Brain

Figure 40 P-1, s10 Amy = Amygdaloid nuclei CA1 = CA1 field of hippocampus CA3 = CA3 field of hippocampus cc = Corpus callosum CPu = Caudate putamen FrCtx = Frontal cortex GP = Globus pallidus

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10/26/10 4:31:40 PM

Sagittal Plates

43

Figure 41 P-1, s11 cc = Corpus callosum cer = Cerebellum Cpu = Caudate putamen dhippo = Dorsal hippocampal formation FrCtx = Frontal cortex vhippo = Ventral hippocampal formation

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44

Atlas of the Neonatal Rat Brain

Figure 42 P-1, s12 Amy = Amygdaloid nuclei Cpu = Caudate putamen dhippo = Dorsal hippocampal formation FrCtx = Frontal cortex OCtx = Olfactory cortex vhippo = Ventral hippocampal formation

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10/26/10 4:31:42 PM

Sagittal Plates

45

Figure 43 P-1, s13 Amy = Amygdaloid nuclei Cpu = Caudate putamen Hfor = Hippocampal formation neoCtx = Neocortex OCtx = Olfactory cortex

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46

Atlas of the Neonatal Rat Brain

Figure 44 P-1, s14 Ctx = Cortex

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10/26/10 4:31:43 PM

Section II

P-7 Brain

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Coronal Plates

49

Coronal Plates

Figure 45 P-7, c1 EPI = External plexiform layer, olfactory bulb GI = Glomerular layer, olfactory bulb IPI = Internal plexiform layer, olfactory bulb OV = Olfactory ventricle

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10/26/10 4:31:44 PM

50

Atlas of the Neonatal Rat Brain

Figure 46 P-7, -c2 AO = Anterior olfactory bulb E = Ependyma and subependymal layer OCtx = Orbital cortex OV = Olfactory ventricle

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10/26/10 4:31:44 PM

Coronal Plates

51

Figure 47 P-7, c3 AO = Anterior olfactory bulb E = Ependyma and subependymal layer FrCtx = Frontal cortex OCtx = Orbital cortex OV = Olfactory ventricle PrCtx = Parietal cortex

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10/26/10 4:31:45 PM

52

Atlas of the Neonatal Rat Brain

Figure 48 P-7, c4 AICtx = Agranular insular cortex CgCtx = Cingulate cortex E = Ependyma and subependymal layer fmi = Forceps minor of corpus callosum MCtx = Motor cortex OCtx = Orbital cortex OV = Olfactory ventricle PrCtx = Parietal cortex

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10/26/10 4:31:46 PM

Coronal Plates

53

Figure 49 P-7, c5 AICtx = Agranular insular cortex AO = anterior olfactory nuclei CgCtx = Cingulate cortex E = Ependyma and subependymal layer fmi = Forceps minor of corpus callosum MCtx = Motor cortex OCtx = Orbital cortex OV = Olfactory ventricle pir = Piriform cortex PrCtx = Parietal cortex

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54

Atlas of the Neonatal Rat Brain

Figure 50 P-7, c6 AICtx = Agranular insular cortex AO = Anterior olfactory nuclei CgCtx = Cingulate cortex E = Ependyma and subependymal layer fmi = Forceps minor of corpus callosum MCtx = Motor cortex OCtx = Orbital cortex OV = Olfactory ventricle pir = Piriform cortex PrCtx = Parietal cortex

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10/26/10 4:31:47 PM

Coronal Plates

Figure 51 P-7, c7 AcbC = Accumbens nucleus core AICtx = Agranular insular cortex CgCtx = Cingulate cortex CPu = Caudate putamen fmi = Forceps minor of corpus callosum

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55

LS = Lateral septal nuclei LV = Lateral ventricle MCtx = Motor cortex pir = Piriform cortex SCtx = Somatosensory cortex

10/26/10 4:31:48 PM

56

Atlas of the Neonatal Rat Brain

Figure 52 P-7, c8 aca = Anterior commissure AcbC = Accumbens nucleus core cc = Corpus callosum CgCtx = Cingulate cortex CPu = Caudate putamen LS = Lateral septal nuclei LV = Lateral ventricle MCtx = Motor cortex pir = Piriform cortex SCtx = Somatosensory cortex

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10/26/10 4:31:48 PM

Coronal Plates

57

Figure 53 P-7, c9 aca = Anterior commissure AICtx = Agranular insular cortex CgCtx = Cingulate cortex cc = Corpus callosum CPu = Caudate putamen ec = external capsule LS = Lateral septal nuclei LV = Lateral ventricle MCtx = Motor cortex pir = Piriform cortex SCtx = Somatosensory cortex

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10/26/10 4:31:49 PM

58

Atlas of the Neonatal Rat Brain

Figure 54 P-7, c10 AICtx = Agranular insular cortex CA3 = CA3 field of hippocampus cc = Corpus callosum CPu = Caudate putamen DG = Dentate gyrus ec = external capsule

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LGP = Lateral globus pallidus LV = Lateral ventricle MCtx = Motor cortex pir = Piriform cortex SCtx = Somatosensory cortex

10/26/10 4:31:50 PM

Coronal Plates

Figure 55 P-7, c11 aca = Anterior commissure AICtx = Agranular insular cortex AVTh = Anteroventral thalamic nucleus CA3 = CA3 field of hippocampus cc = Corpus callosum CPu = Caudate putamen DG = Dentate gyrus ec = External capsule

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59

Hypo = Hypothalamus LGP = Lateral globus pallidus LTh = Lateral thalamic nucleus LV = Lateral ventricle MCtx = Motor cortex pir = Piriform cortex PvTH = Paraventricular thalamic nucleus SCtx = Somatosensory cortex

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60

Atlas of the Neonatal Rat Brain

Figure 56 P-7, c12 AICtx = Agranular insular cortex Amy = Amygdaloid nuclei CA1 = CA1 field of hippocampus CA2 = CA2 field of hippocampus CA3 = CA3 field of hippocampus cc = Corpus callosum CPu = Caudate putamen DG = Dentate gyrus ec = External capsule

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Hypo = Hypothalamus LGP = Lateral globus pallidus LTh = Lateral thalamic nucleus LV = Lateral ventricle MCtx = Motor cortex pir = Piriform cortex PvTH = Paraventricular thalamic nucleus SCtx = Somatosensory cortex

10/26/10 4:31:51 PM

Coronal Plates

Figure 57 P-7, c13 Amy = Amygdaloid nuclei CA1 = CA1 field of hippocampus CA2 = CA2 field of hippocampus CA3 = CA3 field of hippocampus cc = Corpus callosum CPu = Caudate putamen DG = Dentate gyrus ec = External capsule

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61

Hypo = Hypothalamus LGP = Lateral globus pallidus LTh = Lateral thalamic nucleus MCtx = Motor cortex pir = Piriform cortex PvTH = Paraventricular thalamic nucleus SCtx = Somatosensory cortex VTh = Ventral thalamic nucleus

10/26/10 4:31:51 PM

62

Atlas of the Neonatal Rat Brain

Figure 58 P-7, c14 Amy = Amygdaloid nuclei CA1 = CA1 field of hippocampus CA2 = CA2 field of hippocampus CA3 = CA3 field of hippocampus cc = Corpus callosum CPu = Caudate putamen DG = Dentate gyrus ec = External capsule

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Hypo = Hypothalamus LGP = Lateral globus pallidus LTh = Lateral thalamic nucleus MCtx = Motor cortex pir = Piriform cortex PvTH = Paraventricular thalamic nucleus SCtx = Somatosensory cortex VTh = Ventral thalamic nucleus

10/26/10 4:31:52 PM

Coronal Plates

Figure 59 P-7, c15 Amy = Amygdaloid nuclei AuCtx = Auditory cortex CA1 = CA1 field of hippocampus CA2 = CA2 field of hippocampus CA3 = CA3 field of hippocampus DG = Dentate gyrus ec = External capsule Hypo = Hypothalamus LTh = Lateral thalamic nucleus

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63

pir = Piriform cortex PtA = Parietal association cortex PvTH = Paraventricular thalamic nucleus SCtx = Somatosensory cortex SNr = Substantia nigra reticulate VCtx = Visual cortex VTh = Ventral thalamic nucleus ZI = Zona incerta

10/26/10 4:31:53 PM

64

Atlas of the Neonatal Rat Brain

Figure 60 P-7, c16 AuCtx = auditory cortex CA1 = CA1 field of hippocampus CA2 = CA2 field of hippocampus CA3 = CA3 field of hippocampus DG = Dentate gyrus PAG = Periaqueductal gray matter SC = Superior colliculus SNr = Substantia nigra reticulata VCtx = Visual cortex

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10/26/10 4:31:54 PM

Coronal Plates

Figure 61 P-7, c17 AuCtx = Auditory cortex CA3 = CA3 field of hippocampus fmj = Forceps major of corpus callosum Lent = Lateral entorhinal cortex PAG = Periaqueductal gray matter

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65

Pir = Piriform cortex SC = Superior colliculus SNr = Substantia nigra reticulate VCtx = Visual cortex

10/26/10 4:31:54 PM

66

Atlas of the Neonatal Rat Brain

Figure 62 P-7, c18 S = Subiculum DR = Dorsal raphe nucleus PAG = Periaqueductal gray matter SC = Superior colliculus

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10/26/10 4:31:55 PM

Coronal Plates

67

Figure 63 P-7, c19 DR- = Dorsal raphe nucleus PAG = Periaqueductal gray matter Pn = Pontine nucleus SC = Superior colliculus

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10/26/10 4:31:56 PM

68

Atlas of the Neonatal Rat Brain

Figure 64 P-7, c20 CG- = Central gray matter IC = Inferior colliculus

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10/26/10 4:31:57 PM

Coronal Plates

69

Figure 65 P-7, c21 1 through 3 = Cerebellar lobules CG = Central gray matter Crus1 = Crus 1 of ansiform lobule DTg = Dorsal tegmental nuclei IC = Inferior colliculus PTg = Posterior tegmental nuclei Sim = Simple lobule

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10/26/10 4:31:58 PM

70

Atlas of the Neonatal Rat Brain

Figure 66 P-7, c22 Cu- = Cuneate nucleus IC = Inferior colliculus Ve = Vestibular nuclei

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10/26/10 4:31:58 PM

Coronal Plates

71

Figure 67 P-7, c23 1 through 6 = Cerebellar lobules Ve = Vestibular nuclei

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10/26/10 4:31:59 PM

72

Atlas of the Neonatal Rat Brain

Figure 68 P-7, c24 1 through 3 = Cerebellar lobules Ve = Vestibular nuclei

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10/26/10 4:32:00 PM

Coronal Plates

73

Figure 69 P-7, c25 1 = Cerebellar lobule Crus 2 = Crus 2 of ansiform lobule PM = Paramedian lobule

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10/26/10 4:32:01 PM

74

Atlas of the Neonatal Rat Brain

Figure 70 P-7, c26 1 through 6 = Cerebellar lobules Crus 2 = Crus 2 of ansiform lobule PM = Paramedian lobule

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10/26/10 4:32:02 PM

Coronal Plates

75

Figure 71 P-7, c27 Mret = Medullary reticular formation

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10/26/10 4:32:02 PM

76

Atlas of the Neonatal Rat Brain

Sagittal Plates

Figure 72 P-7, s1 Acb = Accumbens nucleus AO = Anterior olfactory bulb CA1 = CA1 field of hippocampus cc = Corpus callosum CgCtx = Cingulate cortex IC = Inferior colliculus MCtx = Motor cortex

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MD = Mediodorsal thalamic nucleus Med = Medulla OCtx = Orbital cortex PrLCtx = Prelimbic cortex SC = Superior colliculus SubM = Submedial thalamic nucleus VCtx = Visual cortex

10/26/10 4:32:03 PM

Sagittal Plates

Figure 73 P-7, s2 AO = Anterior olfactory bulb Acb = Accumbens nucleus CA1 = CA1 field of hippocampus cc = Corpus callosum CgCtx = Cingulate cortex IC = Inferior colliculus MCtx = Motor cortex

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77

MD = Mediodorsal thalamic nucleus Med = Medulla OCtx = Orbital cortex PrLCtx = Prelimbic cortex SC = Superior colliculus Sub = Submedial thalamic nucleus VCtx = Visual cortex

10/26/10 4:32:04 PM

78

Atlas of the Neonatal Rat Brain

Figure 74 P-7, s3 Acb = Accumbens nucleus AO = Anterior olfactory bulb CA1 = CA1 field of hippocampus CA3 = CA3 field of hippocampus cc = Corpus callosum CgCtx = Cingulate cortex DG = Dentate gyrus IAD = Interanterodorsal thalamic nucleus IC = Inferior colliculus MCtx = Motor cortex MDL = Mediodorsal thalamus

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Med = Medulla OCtx = Orbital cortex PAG = Periaqueductal gray matter pcf = Precommissural fornix Pit = Pituitary gland Sub = Submedial thalamic nucleus VCtx = Visual cortex VM = Ventromedial thalamus ZI = Zona incerta

10/26/10 4:32:05 PM

Sagittal Plates

Figure 75 P-7, s4 aca = Anterior commissure Acb = Accumbens nucleus AM = Anteromedial thalamic nucleus Apit = Anterior pituitary gland CA1 = CA1 field of hippocampus CA2 = CA2 field of hippocampus CA3 = CA3 field of hippocampus cc = Corpus callosum DG = Dentate gyrus fmi = Forceps minor of corpus callosum fmj = Forceps major of corpus callosum Hypo = Hypothalamus

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79

IAD = Interanterodorsal thalamic nucleus IC = Inferior colliculus LS = Lateral septal nucleus MCtx = Motor cortex MD = Mediodorsal thalamus OCtx = Orbital cortex OV = Olfactory ventricle PAG = Periaqueductal gray matter Sub = Submedian thalamic nucleus VCtx = Visual cortex ZI = Zona incerta

10/26/10 4:32:05 PM

80

Atlas of the Neonatal Rat Brain

Figure 76 P-7, s5 aca = Anterior commissure Acb = Accumbens nucleus AM = Anteromedial thalamic nucleus Apit =Anterior pituitary gland CA1 = CA1 field of hippocampus CA2 = CA2 field of hippocampus CA3 = CA3 field of hippocampus cc = Corpus callosum DG = Dentate gyrus fmi = Forceps minor of corpus callosum fmj = Forceps major of corpus callosum

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Hypo = Hypothalamus IC = Inferior colliculus LS = Lateral septal nucleus MCtx = Motor cortex MD = Mediodorsal thalamus OCtx = Orbital cortex OV = Olfactory ventricle PAG = Periaqueductal gray matter Sub = Submedian thalamic nucleus VCtx = Visual cortex

10/26/10 4:32:06 PM

Sagittal Plates

Figure 77 P-7, s6 AP = Anteroposterior thalamus APit = Anterior pituitary gland AV = Anteroventral thalamus CA1 = CA1 field of hippocampus CA2 = CA2 field of hippocampus CA3 = CA3 field of hippocampus cc = Corpus callosum CPu = Caudate putamen DG = Dentate gyrus fmi = Forceps minor of corpus callosum fmj = Forceps major of corpus callosum Hypo = Hypothalamus

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81

IC = Inferior colliculus LD = Laterodorsal thalamic nucleus MCtx = Motor cortex Med = Medulla OCtx = Orbital cortex PM = Paramedian lobule Po = Posterior thalamic nucleus group SCtx = Somatosensory cortex SNr = Substantia nigra reticulata VCtx = Visual cortex VT = Ventral thalamus

10/26/10 4:32:07 PM

82

Atlas of the Neonatal Rat Brain

Figure 78 P-7, s7 2 through 6 = Cerebellar lobules AO = Anterior olfactory bulb AP = Anteroposterior thalamus APit = Anterior pituitary gland AV = Antero ventral thalamus CA1 = CA1 field of hippocampus CA2 = CA2 field of hippocampus CA3 = CA3 field of hippocampus cc = Corpus callosum cp = Caudate peduncle CPu = Caudate putamen DG = Dentate gyrus fmi = Forceps minor of corpus callosum fmj = Forceps major of corpus callosum Hypo = Hypothalamus

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IC = Inferior colliculus LD = Laterodorsal thalamic nuclei MCtx = Motor cortex Med = Medulla OCtx = Orbital cortex PM = Paramedian lobule Po = Posterior thalamic nucleus group SCtx = Somatosensory cortex Sim = Simple lobule SNc = Substantia nigra compacta SNr = Substantia nigra reticulata STn = Subthalamic nucleus VCtx = Visual cortex VT = Ventral thalamus ZI = Zona incerta

10/26/10 4:32:08 PM

Sagittal Plates

Figure 79 P-7, s8 2 through 5 = Cerebellar lobules aca = Anterior commissure AcbSh = Accumbens nucleus shell AO = Anterior olfactory bulb CA1 = CA1 field of hippocampus CA2 = CA2 field of hippocampus CA3 = CA3 field of hippocampus cc = Corpus callosum CPu = Caudate putamen Crus1 = Crus 1 of ansiform lobule Crus2 = Crus 2 of ansiform lobule DG = Dentate gyrus fmi = Forceps minor of corpus callosum fmj = Forceps major of corpus callosum

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83

IC = Inferior colliculus LDVL = Laterodorsal ventral thalamic nuclei LGP = Lateral globus pallidus MCtx = Motor cortex opt = Optic tract Po = Posterior thalamus SCtx = Somatosensory cortex sim = Simple lobule STn = Subthalamic nucleus VCtx = Visual cortex VL = Ventrolateral thalamic nucleus VPM = Ventroposteromedial thalamic nucleus VT = Ventral thalamus ZI = Zona incerta

10/26/10 4:32:08 PM

84

Atlas of the Neonatal Rat Brain

Figure 80 P-7, s9 2 through 5 = Cerebellar lobules aca = Anterior commissure AcbSh = Accumbens nucleus shell AO = Anterior olfactory bulb CA1 = CA1 field of hippocampus CA2 = CA2 field of hippocampus CA3 = CA3 field of hippocampus cc = Corpus callosum CPu = Caudate putamen Crus1 = Crus 1 of ansiform lobule Crus2 = Crus 2 of ansiform lobule DG = Dentate gyrus fmi = Forceps minor of corpus callosum fmj = Forceps major of corpus callosum IC = Inferior colliculus LDVL = Laterodorsal ventral thalamic nucleus

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LGP = Lateral globus pallidus MCtx = Motor cortex opt = Optic tract Po = Posterior thalamus SC = Superior colliculus SCtx = Somatosensory cortex sim = Simple lobule SNc = Substantia nigra compacta SNr = Substantia nigra reticulata STn = Subthalamic nucleus VCtx = Visual cortex VL = Ventrolateral thalamic nucleus VPM = Ventral posterior medial thalamic nucleus VT = Ventral thalamus ZI = Zona incerta

10/26/10 4:32:09 PM

Sagittal Plates

Figure 81 P-7, s10 aca = Anterior commissure Amy = Amygdala CA1 = CA1 field of hippocampus CA2 = CA2 field of hippocampus CA3 = CA3 field of hippocampus cc = Corpus callosum Cp = Caudate peduncle CPu = Caudate putamen DG = Dentate gyrus fmj = Forceps major of corpus callosum LDVL = Laterodorsal ventral thalamus

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85

LGP = Lateral globus pallidus MCtx = Motor cortex Pir = Piriform cortex PM = Paramedian lobule Po = Posterior thalamic nucleus group SCtx = Somatosensory cortex SNr = Substantia nigra reticulata STn = Subthalamic nucleus VCtx = Visual cortex VT = Ventral thalamus ZI = Zona incerta

10/26/10 4:32:10 PM

86

Atlas of the Neonatal Rat Brain

Figure 82 P-7, s11 AICtx = Agranular insular cortex Bamy = Basal amygdala CA1 = CA1 field of hippocampus CA2 = CA2 field of hippocampus CA3 = CA3 field of hippocampus cc = Corpus callosum CPu = Caudate putamen DG = Dentate gyrus ec = external capsule Ic = Internal capsule LGP = Lateral globus pallidus

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LTh = Lateral thalamus MCtx = Motor cortex MEnt = Medial entorhinal cortex OCtx = Orbital cortex Pir = Piriform cortex Po = Posterior thalamic nucleus group SCtx = Somatosensory cortex S = Subiculum VCtx = Visual cortex VTh = Ventral thalamus

10/26/10 4:32:11 PM

Sagittal Plates

Figure 83 P-7, s12 AICtx = Agranular insular cortex Bamy = basal amygdala CA1 = CA1 field of hippocampus CA2 = CA2 field of hippocampus CA3 = CA3 field of hippocampus cc = Corpus callosum CPu = Caudate putamen DG = Dentate gyrus ec = external capsule GN = Geniculate nucleus

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87

Ic = Internal capsule LGP = Lateral globus pallidus MCtx = Motor cortex MEnt = Medial entorhinal cortex OCtx = Orbital cortex Pir = Piriform cortex SCtx = Somatosensory cortex S = Subiculum VCtx = Visual cortex VT = Ventral thalamus

10/26/10 4:32:11 PM

88

Atlas of the Neonatal Rat Brain

Figure 84 P-7, s13 AICtx = Agranular insular cortex Bamy = Basal amygdala CA1 = CA1 field of hippocampus CA2 = CA2 field of hippocampus CA3 = CA3 field of hippocampus cc = Corpus callosum CPu = Caudate putamen DG = Dentate gyrus ec = external capsule GN = Geniculate nucleus

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Ic = Internal capsule LGP = Lateral globus pallidus MCtx = Motor cortex MEnt = Medial entorhinal cortex OCtx = Orbital cortex Pir = Piriform cortex SCtx = Somatosensory cortex S = Subiculum VCtx = Visual cortex VT = Ventral thalamus

10/26/10 4:32:12 PM

Sagittal Plates

Figure 85 P-7, s14 AICtx = Agranular insular cortex Bamy = Basal amygdala CA1 = CA1 field of hippocampus CA2 = CA2 field of hippocampus

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89

CA3 = CA3 field of hippocampus cc = Corpus callosum CPu = Caudate putamen ec = external capsule

10/26/10 4:32:13 PM

90

Atlas of the Neonatal Rat Brain

Figure 86 P-7, s15 AICtx = Agranular insular cortex Bamy = Basal amygdala CA1 = CA1 field of hippocampus CA2 = CA2 field of hippocampus CA3 = CA3 field of hippocampus cc = Corpus callosum CPu = Caudate putamen ec = external capsule fmj = Forceps major corpus callosum

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GP = Globus pallidus Ic = Internal capsule Lamy = Lateral amygdaloid nucleus MCtx = Motor cortex MEnt = Medial entorhinal cortex Pir = Piriform cortex SCtx = Somatosensory cortex VCtx = Visual cortex

10/26/10 4:32:14 PM

Sagittal Plates

Figure 87 P-7, s16 Amy = Amygdaloid nuclei CA1 = CA1 field of hippocampus CA2 = CA2 field of hippocampus CA3 = CA3 field of hippocampus cc = Corpus callosum

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91

CPu = Caudate putamen DG = Dentate gyrus MCtx = Motor cortex SCtx = Somatosensory cortex VCtx = Visual cortex

10/26/10 4:32:15 PM

92

Atlas of the Neonatal Rat Brain

Figure 88 P-7, s17 Amy = Amygdaloid nuclei CA1 = CA1 field of hippocampus CA2 = CA2 field of hippocampus CA3 = CA3 field of hippocampus cc = Corpus callosum

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CPu = Caudate putamen DG = Dentate gyrus MCtx = Motor cortex SCtx = Somatosensory cortex VCtx = Visual cortex

10/26/10 4:32:16 PM

Sagittal Plates

93

Figure 89 P-7, s18 Amy = Amygdaloid nuclei CPu = Caudate putamen dhippo = Dorsal hippocampal formation MCtx = Motor cortex SCtx = Somatosensory cortex VCtx = Visual cortex Vhippo = Ventral hippocampal formation

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94

Atlas of the Neonatal Rat Brain

Figure 90 P-7, s19 CPu = Caudate putamen MCtx = Motor cortex SCtx = Somatosensory cortex Hfor = Hippocampal formation

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Sagittal Plates

95

Figure 91 P-7, s20 Ctx = Cortex Hfor = Hippocampal formation

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96

Atlas of the Neonatal Rat Brain

Figure 92 P-7, s21 Ctx = Cortex

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Sagittal Plates

97

Figure 93 P-7, s22 Ctx = Cortex

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98

Atlas of the Neonatal Rat Brain

Figure 94 P-7, s23 Ctx = Cortex

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Sagittal Plates

99

Figure 95 P-7, s24 Ctx-= Cortex

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Section III

P-14 Brain

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Coronal Plates

103

Coronal Plates

Figure 96 P-14, c1 E = Ependyma and subependymal layer EPI = External plexiform layer, olfactory bulb GI = Glomerular layer, olfactory bulb GrO = Granular cell layer, olfactory bulb OV = Olfactory ventricle

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104

Atlas of the Neonatal Rat Brain

Figure 97 P-14, c2 AO = Anterior olfactory bulb E = Ependyma and subependymal layer OCtx = Orbital cortex OV = Olfactory ventricle

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Coronal Plates

105

Figure 98 P-14, c3 AO = Anterior olfactory bulb E = Ependyma and subependymal layer MCtx = Motor cortex OCtx = Orbital cortex OV = Olfactory ventricle

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106

Atlas of the Neonatal Rat Brain

Figure 99 P-14, c4 AICtx = Agranular insular cortex AO = Anterior olfactory nuclei CgCtx = Cingulate cortex E = Ependyma and subependymal layer fmi = Forceps minor of corpus callosum MCtx = Motor cortex OCtx = Orbital cortex OV = Olfactory ventricle Pir = Piriform cortex PrLCtx = Prelimbic cortex

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Coronal Plates

107

Figure 100 P-14, c5 AICtx = Agranular insular cortex CgCtx = Cingulate cortex fmi = Forceps minor of corpus callosum LV = Lateral ventricle MCtx = Motor cortex pir = Piriform cortex SCtx = Somatosensory cortex

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108

Atlas of the Neonatal Rat Brain

Figure 101 P-14, c6 AICtx = Agranular insular cortex AcbC = Nucleus accumbens core AcbSh = Nucleus accumbens shell CgCtx = Cingulate cortex CPu = Caudate putamen ec = external capsule

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fmi = Forceps minor of corpus callosum LV = Lateral ventricle MCtx = Motor cortex pir = Piriform cortex SCtx = Somatosensory cortex

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Coronal Plates

109

Figure 102 P-14, c7 AICtx = Agranular insular cortex AcbC = Nucleus accumbens core AcbSh = Nucleus accumbens shell CgCtx = Cingulate cortex CPu = Caudate putamen ec = external capsule fmi = Forceps minor of corpus callosum LV = Lateral ventricle MCtx = Motor cortex pir = Piriform cortex SCtx = Somatosensory cortex

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110

Atlas of the Neonatal Rat Brain

Figure 103 P-14, c8 aca = Anterior commissure CgCtx = Cingulate cortex CPu = Caudate putamen cc = Corpus callosum LS = Lateral septal nuclei LV = Lateral ventricle MCtx = Motor cortex pir = Piriform cortex SCtx = Somatosensory cortex

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Coronal Plates

111

Figure 104 P-14, c9 aca = Anterior commissure CgCtx = Cingulate cortex CPu = Caudate putamen cc = Corpus callosum LSI = Lateral septal nuclei MCtx = Motor cortex pir = Piriform cortex SCtx = Somatosensory cortex

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112

Atlas of the Neonatal Rat Brain

Figure 105 P-14, c10 cc = Corpus callosum CgCtx = Cingulate cortex CPu = Caudate putamen LSI = Lateral septal nuclei MCtx = Motor cortex pir = Piriform cortex SCtx = Somatosensory cortex

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Coronal Plates

113

Figure 106 P-14, c11 cc = Corpus callosum CPu = Caudate putamen LSI = Lateral septal nuclei MCtx = Motor cortex pir = Piriform cortex SCtx = Somatosensory cortex

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114

Atlas of the Neonatal Rat Brain

Figure 107 P-14, c12 cc = Corpus callosum CgCtx = Cingulate cortex CPu = Caudate putamen Ec = External capsule LV = Lateral ventricle MCtx = Motor cortex pir = Piriform cortex SCtx = Somatosensory cortex

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Coronal Plates

Figure 108 P-14, c13 cc = Corpus callosum CgCtx = Cingulate cortex CPu = Caudate putamen D3V = Dorsal third ventricle fi = Fimbria of hippocampus

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115

LGP = Lateral globus pallidus MCtx = Motor cortex pir = Piriform cortex SCtx = Somatosensory cortex

10/26/10 4:32:33 PM

116

Atlas of the Neonatal Rat Brain

Figure 109 P-14, c14 AT = Anterior thalamus CA3 = CA3 field of hippocampus cc = Corpus callosum CPu = Caudate putamen ec = external capsule LGP = Lateral globus pallidus MCtx = Motor cortex pir = Piriform cortex SCtx = Somatosensory cortex

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Coronal Plates

117

Figure 110 P-14, c15 AT = Anterior thalamus CA3 = CA3 field of hippocampus cc = Corpus callosum CPu = Caudate putamen DG = Dentate gyrus ec = external capsule LGP = Lateral globus pallidus MCtx = Motor cortex pir = Piriform cortex SCtx = Somatosensory cortex

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118

Atlas of the Neonatal Rat Brain

Figure 111 P-14, c16 AICtx = Agranular insular cortex Amy = Amygdaloid nuclei AT = Anterior thalamus AICtx = Agranular insular cortex CA3 = CA3 field of hippocampus cc = Corpus callosum CPu = Caudate putamen

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DG = Dentate gyrus ec = external capsule hypo = Hypothalamus LGP = Lateral globus pallidus MCtx = Motor cortex pir = Piriform cortex SCtx = Somatosensory cortex

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Coronal Plates

Figure 112 P-14, c17 AICtx = Agranular insular cortex Amy = Amygdaloid nuclei AT = Anterior thalamus CA3 = CA3 field of hippocampus cc = Corpus callosum CPu = Caudate putamen DG = Dentate gyrus

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119

ec = external capsule hypo = Hypothalamus LDVL = Lateral dorsoventral thalamus LGP = Lateral globus pallidus MCtx = Motor cortex pir = Piriform cortex SCtx = Somatosensory cortex

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120

Atlas of the Neonatal Rat Brain

Figure 113 P-14, c18 AICtx = Agranular insular cortex Amy = Amygdaloid nuclei AT = Anterior thalamus CA3 = CA3 field of hippocampus cc = Corpus callosum CPu = Caudate putamen DG = Dentate gyrus

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ec = external capsule hypo = Hypothalamus LDVL = Lateral dorsoventral thalamus LGP = Lateral globus pallidus MCtx = Motor cortex SCtx = Somatosensory cortex VT = Ventral thalamus

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Coronal Plates

Figure 114 P-14, c19 AICtx = Agranular insular cortex Amy = Amygdaloid nucleus CA1 = CA1 field of hippocampus CA2 = CA2 field of hippocampus CA3 = CA3 field of hippocampus cc = Corpus callosum CPu = Caudate putamen DG = Dentate gyrus

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121

ec = external capsule hypo = Hypothalamus LDVL = Lateral dorsoventral thalamus MCtx = Motor cortex MT = Medial thalamus SCtx = Somatosensory cortex VT = Ventral thalamus

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122

Atlas of the Neonatal Rat Brain

Figure 115 P-14, c20 AICtx = Agranular insular cortex Amy = Amygdaloid nuclei CA1 = CA1 field of hippocampus CA2 = CA2 field of hippocampus CA3 = CA3 field of hippocampus cc = Corpus callosum CPu = Caudate putamen DG = Dentate gyrus

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ec = external capsule hypo = Hypothalamus LDVL = Lateral dorsoventral thalamus LGP = Lateral globus pallidus MCtx = Motor cortex MT = Medial thalamus SCtx = Somatosensory cortex VT = Ventral thalamus

10/26/10 4:32:39 PM

Coronal Plates

Figure 116 P-14, c21 Amy = Amygdaloid nuclei AuCtx = Auditory cortex CA1 = CA1 field of hippocampus CA2 = CA2 field of hippocampus CA3 = CA3 field of hippocampus cc = Corpus callosum CM = Central medial thalamic nucleus CPu = Caudate putamen DG = Dentate gyrus ec = external capsule

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123

hypo = Hypothalamus LT = Lateral thalamus MT = Medial thalamus Po = Posterior thalamic nucleus group PtACtx = Parietal association cortex RsCtx = Retrospenial cortex SCtx = Somatosensory cortex VT = Ventral thalamus ZI = Zona incerta

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124

Atlas of the Neonatal Rat Brain

Figure 117 P-14, c22 Amy = Amygdaloid nuclei AuCtx = Auditory cortex CA1 = CA1 field of hippocampus CA2 = CA2 field of hippocampus CA3 = CA3 field of hippocampus cc = Corpus callosum CM = Central medial thalamic nucleus DG = Dentate gyrus ec = external capsule hypo = Hypothalamus

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LTh = Lateral thalamus MT = Medial thalamus pir = Piriform cortex Po = Posterior thalamic nucleus group PtACtx = Parietal association cortex RsCtx = Retrospenial cortex SCtx = Somatosensory cortex STn = Subthalamic nucleus VT = Ventral thalamus ZI = Zona incerta

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Coronal Plates

Figure 118 P-14, c23 Amy = Amygdaloid nuclei AuCtx = Auditory cortex CA1 = CA1 field of hippocampus CA2 = CA2 field of hippocampus CA3 = CA3 field of hippocampus DG = Dentate gyrus LT = Lateral thalamus

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125

Lent = Lateral entorhinal cortex pir = Piriform cortex PtACtx = Parietal association cortex RsCtx = Retrospenial cortex SNr = Substantia nigra reticulata VCtx = Visual cortex ZI = Zona incerta

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126

Atlas of the Neonatal Rat Brain

Figure 119 P-14, c24 Amy = Amygdaloid nuclei AuCtx = Auditory cortex CA1 = CA1 field of hippocampus CA2 = CA2 field of hippocampus CA3 = CA3 field of hippocampus DG = Dentate gyrus Lent = Lateral entorhinal cortex LPAG = Lateral periaqueductal gray matter

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LT = Lateral thalamus MGN = Medial geniculate nucleus pir = Piriform cortex PtACtx = Parietal association cortex RsCtx = Retrospenial cortex SNr = Substantia nigra reticulata VCtx = Visual cortex ZI = Zona incerta

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Coronal Plates

127

Figure 120 P-14, c25 Amy = Amygdaloid nuclei AuCtx = Auditory cortex CA1 = CA1 field of hippocampus CA2 = CA2 field of hippocampus CA3 = CA3 field of hippocampus Lent = Lateral entorhinal cortex MGN = Medial geniculate nucleus PAG = Periaqueductal gray matter Pir = Piriform cortex RsCtx = Retrospenial cortex SC = Superior colliculus SNr = Substantia nigra reticulate

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128

Atlas of the Neonatal Rat Brain

Figure 121 P-14, c26 Amy = Amygloid nucleus AuCtx = Auditory cortex CA1 = CA1 field of hippocampus CA2 = CA2 field of hippocampus CA3 = CA3 field of hippocampus PAG = Periaqueductal gray Pir = Piriform cortex MGN = Medial geniculate nucleus RsCtx = Retrospenial cortex SC = Superior colliculus SNr = Substantia nigra, reticulata

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Coronal Plates

129

Figure 122 P-14, c27 Lent = Lateral entorhinal cortex PAG = Periaqueductal gray matter RsCtx = Retrospenial cortex S = Subiculum SC = Superior colliculus SNr = Substantia nigra reticulata VCtx = Visual cortex

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130

Atlas of the Neonatal Rat Brain

Figure 123 P-14, c28 Hf = Hippocampal fissure Lent = Lateral entorhinal cortex PAG = Periaqueductal gray matter RsCtx = Retrospenial cortex S = Subiculum SC = Superior colliculus SNr = Substantia nigra reticulata VCtx = Visual cortex

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Coronal Plates

131

Figure 124 P-14, c29 fmj = Forceps major of corpus callosum IC = Inferior colliculus PAG = Periaqueductal gray matter SC = Superior colliculus RsCtx = Retrospenial cortex VCtx = Visual cortex

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132

Atlas of the Neonatal Rat Brain

Figure 125 P-14, c30 fmj = Forceps major of corpus callosum IC = Inferior colliculus Lent = Lateral entorhinal cortex PAG = Periaqueductal gray matter SC = Superior colliculus RsCtx = Retrospenial cortex VCtx = Visual cortex

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Coronal Plates

133

Figure 126 P-14, c31 IC = Inferior colliculus PAG = Periaqueductal gray matter RsCtx = Retrospenial cortex SC = Superior colliculus VCtx = Visual cortex

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134

Atlas of the Neonatal Rat Brain

Figure 127 P-14, c32 2 = Cerebellar lobule DTg = Dorsal tegmental nucleus IC = Inferior colliculus Pn = Pontine reticular nucleus

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Coronal Plates

135

Figure 128 P-14, c33 Cer = Cerebellar nuclei DTg = Dorsal tegmental nucleus IC = Inferior colliculus

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136

Atlas of the Neonatal Rat Brain

Figure 129 P-14, c34 1 through 4 = Cerebellar lobules Crus1 = Crus1 of ansiform lobule Sim = Simple lobule

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Coronal Plates

137

Figure 130 P-14, c35 1 through 4 = Cerebellar lobules Crus1 = Crus1 of ansiform lobule Sim = Simple lobule

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138

Atlas of the Neonatal Rat Brain

Figure 131 P-14, c36 1 through 4 = Cerebellar lobules Crus1 = Crus1 of ansiform lobule Sim = Simple lobule

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Coronal Plates

139

Figure 132 P-14, c37 1 through 6 = Cerebellar lobules Crus1 = Crus1 of ansiform lobule Lat = Lateral cerebellar nucleus Sim = Simple lobule Spn = Spinal nucleus

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140

Atlas of the Neonatal Rat Brain

Figure 133 P-14, c38 6 through 10 = Cerebellar lobules Crus1 = Crus1 of ansiform lobule Crus2 = Crus2 of ansiform lobule plf = Posterolateral fissure

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Coronal Plates

141

Figure 134 P-14, c39 6 through 10 = Cerebellar lobules Crus1 = Crus1 of ansiform lobule Crus2 = Crus2 of ansiform lobule

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142

Atlas of the Neonatal Rat Brain

Figure 135 P-14, c40 cer = Cerebellum Spn = Spinal nucleus

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Coronal Plates

143

Figure 136 P-14, c41 9 = Cerebellar lobule Spn = Spinal nucleus

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144

Atlas of the Neonatal Rat Brain

Sagittal Plates

Figure 137 P-14, S1 4 through 9 = Cerebellar lobules Acb = Accumbens nucleus AO = Anterior olfactory bulb AM = Anteromedial thalamus APit = Anterior pituitary CA3 = CA3 field of hippocampus cc = Corpus callosum CgCtx = Cingulate cortex GI = Glomerular cell layer, olfactory bulb

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IC = Inferior colliculus LS = Lateral septal nucleus MCtx = Motor cortex MDM = Mediodorsal thalamic nucleus PAG = Periaqueductal gray matter PrLCtx = Prelimbic cortex RSCtx = Retrospenial cortex Sub = Submedial thalamic nucleus VH = Ventral hypothalamus

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Sagittal Plates

Figure 138 P-14, s2 4 through 10 = Cerebellar lobules Acb = Accumbens nucleus AM = Anteromedial thalamus AO = Anterior olfactory bulb APit = Anterior pituitary CA3 = CA3 field of hippocampus cc = Corpus callosum CgCtx = Cingulate cortex GI = Glomerular layer olfactory bulb

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145

IC = Inferior colliculus LS = Lateral septal nucleus MCtx = Motor cortex MDM = Mediodorsal thalamic nucleus PAG = Periaqueductal gray matter PrLCtx = Prelimbic cortex RSCtx = Retrospenial cortex Sub = Submedial thalamic nucleus VH = Ventral hypothalamus

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146

Atlas of the Neonatal Rat Brain

Figure 139 P-14, s3 1 through 9 = Cerebellar lobules aca = Anterior commissure AcbSh = Accumbens nucleus shell AM = Anteriomedial thalamus AO = Anterior olfactory bulb APit = Anterior pituitary CA1 = CA1 field of hippocampus CA2 = CA2 field of hippocampus CA3 = CA3 field of hippocampus cc = Corpus callosum CgCtx = Cingulate cortex DG = Dentate gyrus GI = Glomerular layer, olfactory bulb

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IAD = Interanterodorsal thalamic nucleus IC = Inferior colliculus LS = Lateral septal nucleus MCtx = Motor cortex MD = Mediodorsal thalamic nucleus OV= Olfactory ventricle PAG = Periaqueductal gray matter Sub = Submedial thalamic nucleus VCtx = Visual cortex VM = Ventromedial thalamus VO = Ventral orbital cortex ZI = Zona incerta

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Sagittal Plates

Figure 140 P-14, s4 1 through 10 = Cerebellar lobules aca = Anterior commissure AcbSh = Accumbens nucleus shell AM = Anteromedial thalamus AO = Anterior olfactory bulb APit = Anterior pituitary CA1 = CA1 field of hippocampus CA2 = CA2 field of hippocampus CA3 = CA3 field of hippocampus cc = Corpus callosum CgCtx = Cingulate cortex DG = Dentate gyrus GI = Glomerular layer, olfactory bulb

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147

IAD = Interanterodorsal thalamic nucleus IC = Inferior colliculus LS = Lateral septal nucleus MCtx = Motor cortex MD = Mediodorsal thalamic nucleus OV = Olfactory ventricle PAG = Periaqueductal gray matter Sub = Submedial thalamic nucleus VM = Ventral medial thalamus VO = Ventral orbital cortex VCtx = Visual cortex ZI = Zona incerta

10/26/10 4:33:07 PM

148

Atlas of the Neonatal Rat Brain

Figure 141 P-14, S5 2 through 6 = Cerebellar lobules AICtx = Agranular insular cortex AO = Anterior olfactory bulb APT = Anteriorpretectal nucleus AV = Anteroventral thalamus CA1 = CA1 field of hippocampus CA2 = CA2 field of hippocampus CA3 = CA3 field of hippocampus cc = Corpus callosum CgCtx = Cingulate cortex Cop = Copula of pyramis CPu = Caudate putamen Crus2 = Crus2 of ansiform lobule EPI = External plexiform layer, olfactory bulb fmi = Forceps minor of corpus callosum

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fmj = Forceps major of corpus callosum GI = Glomerular layer, olfactory bulb IC = Inferior colliculus MCtx = Motor cortex OCtx = Orbital cortex Pir = Piriform cortex Po = Posterior thalamic nucleus group SCtx = Somatosensory cortex sim = Simple lobule SNr = Substantia nigra reticulata STn = Subthalamic nucleus VCtx = Visual cortex VL = Ventrolateral thalamic nucleus ZI = Zona incerta

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Sagittal Plates

Figure 142 P-14, S6 2 through 6 = Cerebellar lobules AICtx = Agranular insular cortex AO = Anterior olfactory bulb APT = Anteriorpretectal nucleus AV = Anteroventral thalamus CA1 = CA1 field of hippocampus CA2 = CA2 field of hippocampus CA3 = CA3 field of hippocampus cc = Corpus callosum CgCtx = Cingulate cortex Cop = Copula of pyramis CPu = Caudate putamen Crus2 = Crus2 of ansiform lobule EPI = External plexiform layer, olfactory bulb fmi = Forceps minor of corpus callosum fmj = Forceps major of corpus callosum GI = Glomerular layer olfactory bulb

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149

IC = Inferior colliculus LD = Laterodorsal thalamus MCtx = Motor cortex OCtx = Orbital cortex opt = Optic tract Pir = Piriform cortex Po = Posterior thalamic nucleus group SCtx = Somatosensory cortex sim = Simple lobule SNr = Substantia nigra reticulata STn = Subthalamic nucleus VCtx = Visual cortex VL = Ventrolateral thalamic nucleus VM = Ventromedial thalamus VP = Ventral pallidum ZI = Zona incerta

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150

Atlas of the Neonatal Rat Brain

Figure 143 P-14, S7 2 through 5 = Cerebellar lobules AICtx = Agranular insular cortex AO = Anterior olfactory bulb Bamy = Basal amygdala CA1 = CA1 field of hippocampus CA2 = CA2 field of hippocampus CA3 = CA3 field of hippocampus cc = Corpus callosum cp = Caudate peduncle CPu = Caudate putamen Crus2 = Crus1 of ansiform lobule EPI = External plexiform layer, olfactory bulb fmi = Forceps minor of corpus callosum fmj = Forceps major of corpus callosum GI = Glomerular layer, olfactory bulb IC = Inferior colliculus Ic = Internal capsule LD = Laterodorsal thalamic nucleus

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LGP = Lateral globus pallidus MCtx = Motor cortex MEnt = Medial entorhinal cortex MEPD = Medial amygdala nucleus MGD = Medial geniculate nucleus, dorsal MGV = Medial geniculate nucleus, ventral OCtx = Orbital cortex opt = Optic tract Pir = Piriform cortex SCtx = Somatosensory cortex Sim = Simple lobule SNr = Substantia nigra reticulata STn = Subthalamic nucleus VCtx = Visual cortex VPM = Ventroposteromedial thalamic nucleus VPL = ventroposterolateral thalamic nucleus VM = Ventromedial thalamus ZI = Zona incerta

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Sagittal Plates

Figure 144 P-14, S8 2 through 4 = Cerebellar lobules AICtx = Agranular insular cortex AO = Anterior olfactory bulb Bamy = Basal amygdala CA1 = CA1 field of hippocampus CA2 = CA2 field of hippocampus CA3 = CA3 field of hippocampus cc = Corpus callosum CPu = Caudate putamen Crus1 = Crus1 of ansiform lobule Crus2 = Crus2 of ansiform lobule EPI = External plexiform layer, olfactory bulb fmi = Forceps minor of corpus callosum fmj = Forceps major of corpus callosum GI = Glomerular layer, olfactory bulb IC = Inferior colliculus LDVL = Laterodorsal thalamic nucleus

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151

LGP = Lateral globus pallidus LPLR = Lateroposterior thalamic nucleus LPM = Lateroposteromedial thalamic nucleus MCtx = Motor cortex MEPD = Medial amygdala nucleus OCtx = Orbital cortex opt = Optic tract Pir = Piriform cortex PM = Paramedian lobule SCtx = Somatosensory cortex Sim = Simple lobule SNr = Substantia nigra reticulata STn = Subthalamic nucleus VCtx = Visual cortex VPM = Ventroposterimedial thalamic nucleus VPL = Ventroposterolateral thalamic nucleus ZI = Zona incerta

10/26/10 4:33:10 PM

152

Atlas of the Neonatal Rat Brain

Figure 145 P-14, S9 2 through 5 = Cerebellar lobules AICtx = Agranular insular cortex AO = Anterior olfactory bulb Bamy = Basal amygdala CA1 = CA1 field of hippocampus CA2 = CA2 field of hippocampus CA3 = CA3 field of hippocampus cc = Corpus callosum cp = Caudate peduncle CPu = Caudate putamen Crus1 = Crus1 of ansiform lobule Crus2 = Crus2 of ansiform lobule EPI = External plexiform layer, olfactory bulb fmi = Forceps minor of corpus callosum fmj = Forceps major of corpus callosum GI = Glomerular layer, olfactory bulb IC = Inferior colliculus Ic = Internal capsule

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LDL = Laterodorsal thalamic nucleus LGP = Lateral globus pallidus MCtx = Motor cortex MEnt = Medial entorhinal cortex MEPD = Medial amygdala nucleus MGD = Medial geniculate nucleus, dorsal MGV = Medial geniculate nucleus, ventral OCtx = Orbital cortex opt = Optic tract Pir = Piriform cortex PM = Paramedian lobule SCtx = Somatosensory cortex Sim = Simple lobule SN = Substantia nigra VCtx = Visual cortex VPL = Ventroposterolateral thalamic nucleus VPM = Ventroposteromedial thalamic nucleus ZI = Zona incerta

10/26/10 4:33:10 PM

Sagittal Plates

Figure 146 P-14, S10 Bamy = Basal amygdala CA1 = CA1 field of hippocampus CA2 = CA2 field of hippocampus CA3 = CA3 field of hippocampus cc = Corpus callosum CPu = Caudate putamen fmj = Forceps major of corpus callosum LT = Lateral thalamus LGP = Lateral globus pallidus

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153

MCtx = Motor cortex MGN = Medial geniculate nucleus Pir = Piriform cortex SCtx = Somatosensory cortex Sim = Simple lobule VCtx = Visual cortex VO = Ventral orbital cortex VT = Ventral thalamus

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154

Atlas of the Neonatal Rat Brain

Figure 147 P-14, S11 AICtx = Agranular insular cortex Bamy = Basal amygdala CA1 = CA1 field of hippocampus CA2 = CA2 field of hippocampus CA3 = CA3 field of hippocampus cc = Corpus callosum CPu = Caudate putamen DLG = Dorsolateral geniculate nucleus fmj = Forceps major of corpus callosum Ic = Internal capsule

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Lent = Lateral entorhinal cortex LGP = Lateral globus pallidus MCtx = Motor cortex MEnt = Medial entorhinal cortex MGV = Medial geniculate nucleus Pir = Piriform cortex SCtx = Somatosensory cortex SubG = Subgeniculate nucleus VCtx = Visual cortex VPL = Ventroposterolateral thalamic nucleus

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Sagittal Plates

155

Figure 148 P-14, S12 AICtx = Agranular insular cortex amy = Amygdala CA1 = CA1 field of hippocampus CA2 = CA2 field of hippocampus CA3 = CA3 field of hippocampus cc = Corpus callosum CPu = Caudate putamen fmj = Forceps major of corpus callosum MCtx = Motor cortex Pir = Piriform cortex SCtx = Somatosensory cortex VCtx = Visual cortex

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156

Atlas of the Neonatal Rat Brain

Figure 149 P-14, S13 AICtx = Agranular insular cortex amy = Amygdala CA1 = CA1 field of hippocampus CA2 = CA2 field of hippocampus CA3 = CA3 field of hippocampus cc = Corpus callosum CPu = Caudate putamen DG = Dentate gyrus

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Ent = Entorhinal cortex fmj = Forceps major of corpus callosum MCtx = Motor cortex Pir = Piriform cortex PrS = Presubiculum SCtx = Somatosensory cortex VCtx = Visual cortex

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Sagittal Plates

Figure 150 P-14, S14 AICtx = Agranular insular cortex alv = Alveus of hippocampus BLA = Basolateral amygdala CA1 = CA1 field of hippocampus CA2 = CA2 field of hippocampus CA3 = CA3 field of hippocampus cc = Corpus callosum CPu = Caudate putamen

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157

DG = Dentate gyrus Ent = Entorhinal cortex MCtx = Motor cortex opt = Optic tract Pir = Piriform cortex S = Subiculum SCtx = Somatosensory cortex VCtx = Visual cortex

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Atlas of the Neonatal Rat Brain

Figure 151 P-14, S15 AICtx = Agranular insular cortex alv = Alveus of hippocampus CA1 = CA1 field of hippocampus CA2 = CA2 field of hippocampus CA3 = CA3 field of hippocampus cc = Corpus callosum CPu = Caudate putamen

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DG = Dentate gyrus Ent = Entorhinal cortex MCtx = Motor cortex Pir = Piriform cortex S = Subiculum SCtx = Somatosensory cortex VCtx = Visual cortex

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Sagittal Plates

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Figure 152 P-14, S16 CA1 = CA1 field of hippocampus CA2 = CA2 field of hippocampus CA3 = CA3 field of hippocampus cc = Corpus callosum CPu = Caudate putamen DG = Dentate gyrus MCtx = Motor cortex SCtx = Somatosensory cortex VCtx = Visual cortex

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Atlas of the Neonatal Rat Brain

Figure 153 P-14, S17 Hfor = Hippocampal formation

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Sagittal Plates

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Figure 154 P-14, S18 Ctx = Cortex

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Atlas of the Neonatal Rat Brain

Figure 155 P-14, S19 Ctx = Cortex

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Sagittal Plates

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Figure 156 P-14, S20 Ctx = Cortex

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164

Atlas of the Neonatal Rat Brain

Figure 157

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