The Role of DNA Damage and Repair in Cell Aging [1 ed.] 978-0-444-50494-4

Aging occurs at the level of individual cells, a complex interplay between intrinsic "programming" and exogeno

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English Pages 1-257 [251] Year 2001

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Table of contents :
Content:
Introduction
Page vii
Barbara A. Gilchrest, Vilhelm A. Bohr

Aging in mitotic and post-mitotic cells Original Research Article
Pages 1-16
Judith Campisi, Huber R. Warner

Age-associated changes in DNA repair and mutation rates Original Research Article
Pages 17-30
Lawrence Grossman, Shin-Ichi Moriwaki, Satyajit Ray, Robert E. Tarone, Qingyi Wei, Kenneth H. Kraemer

Relationship of DNA repair capacity to species lifespan Original Research Article
Pages 31-39
R.W. Hart, A. Turturro, S.Y. Li

DNA base modifications in aging Original Research Article
Pages 41-72
James Warren Gaubatz

Models for stuyding genomic instability during aging Original Research Article
Pages 73-90
Jan Vijg, Heidi Giese, Martijn E.T. Dollé

Effects of aging on gene specific repair Original Research Article
Pages 91-111
Arlan Richardson, ZhongMao Guo

Poly(ADP-ribose) polymerase and aging Original Research Article
Pages 113-133
Dean S. Rosenthal, Cynthia M. Simbulan-Rosenthal, Wen Fang Liu, Mark E. Smulson

DNA instability, telomere dynamics, and cell transformation Original Research Article
Pages 135-151
Robert J. Shmookler Reis, Masood A. Shammas

Commitment signalling for apoptosis, or DNA repair and its relevance to aging and age-dependent diseases Original Research Article
Pages 153-189
Eugenia Wang, Richard Marcotte, Harry T. Papaconstantinou, John Papaconstantinou

DNA damage and its processing with aging: Human premature aging syndromes as model systems Original Research Article
Pages 191-206
Vilhelm A. Bohr

Gene action at the werner helicase locus: its role in the pathobiology of aging Original Research Article
Pages 207-226
Junko Oshima, George M. Martin, Matthew D. Gray, Martin Poot, Peter S. Rabinovitch

Inducible photoprotection in skin: Evidence for a eukaryotic SOS response Original Research Article
Pages 227-253
Mark S. Eller, Barbara A. Gilchrest

Contributors
Pages 255-256

The Role of DNA Damage and Repair in Cell Aging [1 ed.]
 978-0-444-50494-4

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