Structure and Function of GPCRs [1st ed. 2019.] 9783030245917, 3030245918
This book introduces readers to the latest advances in G protein-coupled receptor (GPCR) biology. It reviews our current
316 36 2KB
English Pages 289 [299] Year 2019
Table of contents :
Front Matter ....Pages i-xiv
Structures of Non-rhodopsin GPCRs Elucidated Through X-Ray Crystallography (Chady Nasrallah, Guillaume Lebon)....Pages 1-26
NMR Spectroscopy for the Characterization of GPCR Energy Landscapes (Marina Casiraghi, Jean-Louis Banères, Laurent J. Catoire)....Pages 27-52
Structure and Activation Mechanism of GPCRs (A. J. Venkatakrishnan)....Pages 53-64
Structure-Based Discovery of GPCR Ligands from Crystal Structures and Homology Models (Anirudh Ranganathan, David Rodríguez, Jens Carlsson)....Pages 65-99
Integration on Ligand and Structure Based Approaches in GPCRs (Anil K. Saxena, Shome S. Bhunia, Mridula Saxena)....Pages 101-161
Biased Agonist Pharmacochaperones: Small Molecules in the Toolbox for Selectively Modulating GPCR Activity (Bernard Mouillac, Christiane Mendre)....Pages 163-180
Endosomal PTH Receptor Signaling Through cAMP and Its Consequence for Human Medicine (Ieva Sutkeviciute, Frederic G. Jean-Alphonse, Jean-Pierre Vilardaga)....Pages 181-193
Structure and Function Studies of GPCRs by Site-Specific Incorporation of Unnatural Amino Acids (Meilin Tian, Qian Wang, Chonggang Yuan, Shixin Ye)....Pages 195-215
Fluorescent-Based Strategies to Investigate G Protein-Coupled Receptors: Evolution of the Techniques to a Better Understanding (Orestis Faklaris, Joyce Heuninck, Amandine Falco, Elise Goyet, Jurriaan M. Zwier, Jean-Philippe Pin et al.)....Pages 217-252
Modulation of Metabotropic Glutamate Receptors by Orthosteric, Allosteric, and Light-Operated Ligands (Cyril Goudet, Xavier Rovira, Philippe Rondard, Jean-Philippe Pin, Amadeu Llebaria, Francine Acher)....Pages 253-284
Back Matter ....Pages 285-289
Front Matter ....Pages i-xiv
Structures of Non-rhodopsin GPCRs Elucidated Through X-Ray Crystallography (Chady Nasrallah, Guillaume Lebon)....Pages 1-26
NMR Spectroscopy for the Characterization of GPCR Energy Landscapes (Marina Casiraghi, Jean-Louis Banères, Laurent J. Catoire)....Pages 27-52
Structure and Activation Mechanism of GPCRs (A. J. Venkatakrishnan)....Pages 53-64
Structure-Based Discovery of GPCR Ligands from Crystal Structures and Homology Models (Anirudh Ranganathan, David Rodríguez, Jens Carlsson)....Pages 65-99
Integration on Ligand and Structure Based Approaches in GPCRs (Anil K. Saxena, Shome S. Bhunia, Mridula Saxena)....Pages 101-161
Biased Agonist Pharmacochaperones: Small Molecules in the Toolbox for Selectively Modulating GPCR Activity (Bernard Mouillac, Christiane Mendre)....Pages 163-180
Endosomal PTH Receptor Signaling Through cAMP and Its Consequence for Human Medicine (Ieva Sutkeviciute, Frederic G. Jean-Alphonse, Jean-Pierre Vilardaga)....Pages 181-193
Structure and Function Studies of GPCRs by Site-Specific Incorporation of Unnatural Amino Acids (Meilin Tian, Qian Wang, Chonggang Yuan, Shixin Ye)....Pages 195-215
Fluorescent-Based Strategies to Investigate G Protein-Coupled Receptors: Evolution of the Techniques to a Better Understanding (Orestis Faklaris, Joyce Heuninck, Amandine Falco, Elise Goyet, Jurriaan M. Zwier, Jean-Philippe Pin et al.)....Pages 217-252
Modulation of Metabotropic Glutamate Receptors by Orthosteric, Allosteric, and Light-Operated Ligands (Cyril Goudet, Xavier Rovira, Philippe Rondard, Jean-Philippe Pin, Amadeu Llebaria, Francine Acher)....Pages 253-284
Back Matter ....Pages 285-289
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