Remarks on a Point Set Constructed by Antoine

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MA THEMA TICS: J. W. ALEXA NDER

PROC. N. A. S.

may close down upon the points K by a system of spheres rather than by a complicated system of linking anchor rings. This example shows that a proof of the generalized Sch6nfliess theorem announced by me two years ago, but never published, is erroneous.

REMARKS ON A POINT SET CONSTRUCTED BY ANTOINE By J. W. ALZXANDZR. DEPARTMiNT OF MATaMATICS, PRINCETON UNIVERSITY

Communicated, November 16, 1923

From the consideration of a remarkable point set discovered by Antoine, the following two theorems may be derived: Theorem i. There exists a simple closed surface of genus 0 in 3-space such that the interior of the surface is not simply connected but has, on the contrary, an infinite group. Theorem 2. There exists a simple closed curve in 3-space which is not knotted, inasmuch as it bounds a 2-cell without singularities, and yet such that its group' (as defined by Dehn) is not the same as the group of a circle in 3-space. It follows without difficulty from the second theorem that if an isotopic deformation be defined in the customary manner (cf. for example, Veblen's Cambridge Colloquium Lectures), the group of a curve in 3-space is not an isotopic invariant. This suggests that a modified definition of isotopy might be advisable. Antoine's point set is obtainable as follows. Within an anchor ringir in 3-space, we first construct a chain C or anchor rings ri (i = 1, 2, ..., s) such that each ring ri is linked with its immediate predecessor and immediate successor, after the manner of links in an ordinary chain, and such, also, that the last ring 7r, is linked with the first 71, thereby making the chain closed. We further suppose that the chain C is constructed in such a way that it winds once around the axis of the ring 7r. Secondly, we make a similar construction within each of the anchor rings ri, thereby obtaining chains Ci made up of rings 7rij (j = 1, 2, . .., s), and repeat the process indefinitely, obtaining chains C,> within 7rij, Cijk within rijk, and so on. If we think of the system of rings within one of the rings 7r as the image of the system of rings within the ring Xr under a similarity transformation carrying the interior and boundary of ir into the interior and boundary of 7ri, it is clear that the diameters of the rings 7rijk... decrease towards zero as the number of subscripts to their symbols increases. The inner limiting set 2: determined by the infinite sequences of rings ire, 7ri, 7rijk, ... is the

VOL.. 10, 1924

MA THEMA TICS: J. W. ALEXA NDER

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set constructed by Antoine. It has the remarkable property, as was pointed out by its discoverer, of being-totally disconnected, since every ring rijk... separates it into two non-overlapping closed set, but such that every simple closed surface of genus 0 which contains a point of 2 in its interior and a point of 2 in its exterior necessarily meets the set in at least one point. Let me also call attention to the following property which is the key to the present discussion: the group of the region R residual to the set is infinite and requires an infinite number of generators for its definition. This can easily be shown by noticing that the generating circle of any one of the anchor rings 7rijk... links the point set 2 in a manner characteristic to itself which cannot be reproduced by any combination of generating circles of any of the other rings. Therefore, if these generating circles be all deformed in the space exterior to 2 so as to pass through a common point, P, they will determine an infinite number of independent generators of the group. Following Antoine,2 let us now construct a simply connected region in the space R residual to z as follows: We first take a 3-cell E in the space exterior to the ring w- but such that its boundary meets the boundary of the ring ir in the points and boundary points of a 2-cell e. Secondly, in the region between the ring 7r and the rings 7r, (i = 1, 2, ..., s), we take s 3-cells E; (i = 1, 2, . . ., s), such that no two of them have a point or boundary point in common, but such that the boundary of Ei meets the boundary of 7r in the points and boundary points of a 2-cell ti interior to e, and the boundary of the ring 7r in the points and boundary points of a 2-cell e,. The boundary of Es does not, however, meet the boundaries of any of the rings 7rj (i i j). Then, if we combine the 3-cell E with the 3-cells E along the 2-cells ti, we thereby obtain a 3-cell F1 bounded by a surface of genus 0. We now repeat a similar construction within each of the rings 7ri, and so on indefinitely, obtaining successively the 3-cells F1, F2, .... where Fi is obtained by combining F,_, with the new 3-cells constructed at the i'th stage of the process. As is easily shown, the sequence of 3-cells F1, F2, ... approaches a definite limiting 3-cell F bounded by a simple closed surface lo, of genus- 0, which surface contains the set 2. Now, however, since the group of the region R residual to Antoine's point set 2 requires an infinite number of generators, all of which may be located in the space exterior to lo, the group of the space RD exterior to 2:0 must a fortiori require an infinite number of generators. Therefore, the exterior Ro of Io cannot be simply connected. This, proves the first theorem, since. the interior and exterior of 10 may be interchanged by a reflection. It may be remarked, in passing, that, by a theorem which I have proved elsewhere,3 the Betti numbers of the interior and exterior of 20 must nevertheless satisfy the relation P1 = 1; that is to say, every curve in either of these regions is bounding, though it need not bound a 2-cell.

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ZO6LOG Y: W. H. TALIA FERRO

PROC. N. A. S.

The second theorem follows from a theorem by Denjoy to the effect that through the nowhere dense perfect set Z on the surface lo, it must be possible to trace a Jordon curve, J, on 10. Evidently, the group of the 3-dimensional region residual to J requires an infinite number of generators, yet the curve J bounds a 2-cell in the 3-space, namely, one of the two 3-cells into which the curve j subdivides the surface Zo. More properly, the group in question is the group of the portion of 3-space residual to the curve. 2 C. R. Paris Acad. Sci., 171,1920 (66). Trans. Amer. Math. Soc., 23, 1922 (333-349). I

A STUDY OF THE INTERACTION OF HOST AND PARASITE: A REACTION PRODUCT IN INFECTIONS WITH TRYPANOSOMA LEWISI WHICH INHIBITS THE REPRODUCTION OF THE TRYPANOSOMES

By W. H. TALIAFERRO DEPARTMENT OF MEDICAL ZOOLOGY, SCHOOL or HYGIENNE AND PUBLIC H1ALTH, JOHNS HOPKINS UNIVERSITY Communicated, November 27, 1923

Trypanosoma lewvisi, which is a non-pathogenic blood parasite occurring in various species of rats all over the world, offers many opportunities for studying the interaction of host and parasite. In our investigations of the various factors involved in this interaction, one of the most interesting results is the discovery of a specific reaction product, formed in the blood of infected rats, which forces upon the parasite a peculiar cycle of reproductive activity during the course of the infection. Before this reaction product can be described, it is necessary to discuss the general question of the resistance which the host offers against infections with T. lewisi and to outline the normal course of ordinary infections. We use the term resistance (as in our earlier work) to denote collectively those factors, either active or passive, which operate adversely against the parasite and restrict ourselves to a consideration of only that resistance which develops after the parasites have successfully invaded the host. Such a resistance may be roughly measured by making daily determinations of the number of parasites. For example, if the parasites either remain constant or decrease in number, we know some type of resistance is operative. It may be brought about, however, by one or both of two factors viz.: (1) The rate of reproduction of the parasites may be retarded, or (2) the trypanosomes, after they are formed, may be destroyed. Thus: Number of parasites per cmm. of blood = Number produced by repro-