Protein Structure Chasman 9780824740320, 0824740327

291 38 2MB

English Pages 618 Year 2003

Table of contents :
Preface......Page 5
Contents......Page 7
Contributors......Page 10
Structural Biology and Structural Genomics: A Federal Agency Perspective......Page 14
Producing Proteins......Page 21
Crystallization of Membrane Proteins......Page 39
Prospects for High-Throughput Structure Determination by X-Ray Crystallography......Page 67
Prospects for High-Throughput Structure Determination of Proteins by NMR Spectroscopy......Page 107
Automated Molecular Replacement......Page 153
Comparative Protein Structure Modeling......Page 179
Rising Accuracy of Protein Secondary Structure Prediction......Page 219
Novel Fold and Ab Initio Methods for Protein Structure Generation......Page 263
Identifying Errors in Three- Dimensional Protein Models......Page 289
Comparative Analysis and Evolutionary Classi.cation of Protein Structures......Page 327
Automated Genome Functional Annotation for Structural Genomics......Page 361
The Importance of Structure- Based Function Annotation to Drug Discovery......Page 381
The Protein Data Bank......Page 401
The European Bioinformatics Institute Macromolecular Structure Database (E-MSD)......Page 419
Molecular Docking in Structure-Based Design......Page 429
Use of Pharmacophores in Structure-Based Drug Design......Page 465
The Structure of Human Interferon-beta-1a (AvonexRegistered) and its Relation to Activity: A Case Study of the Use of Structural Data in the Arena of Protein Pharmaceuticals......Page 495
G-Protein-Coupled Receptors: Diverse Functions and Shared Mechanisms of Action Interpreted Through the Structure of Rhodopsin......Page 533
Functional Assessment of Amino Acid Variation Caused by Single- Nucleotide Polymorphisms: A Structural View......Page 573
Index......Page 605

Protein Structure Chasman
9780824740320, 0824740327