Protein Kinase CK2 Cellular Function in Normal and Disease States [1 ed.] 3319145436, 9783319145433
Protein kinase CK2 (formerly casein kinase II or 2) is known to play a critical role in the control of cell growth and c
213 3 3KB
English Pages 378 Year 2015
Table of contents :
Front Matter....Pages i-xxiii
Front Matter....Pages 1-1
Yeast Asf1 Protein as Modulator of Protein Kinase CK2 Activity....Pages 3-16
Impressions from the Conformational and Configurational Space Captured by Protein Kinase CK2....Pages 17-33
Structural Basis of CK2 Regulation by Autoinhibitory Oligomerization....Pages 35-47
Maize RNA-Binding Protein ZmTGH: A New Partner for CK2β1 Regulatory Subunit....Pages 49-55
Front Matter....Pages 57-57
CK2 in Organ Development, Physiology, and Homeostasis....Pages 59-79
Protein Kinase CK2: A Window into the Posttranslational Regulation of the E(spl)/HES Repressors from Invertebrates and Vertebrates....Pages 81-107
Tissue-Specific Functions and Regulation of Protein Kinase CK2....Pages 109-123
CK2 Function in the Regulation of Akt Pathway....Pages 125-140
Cellular Zinc Signalling Is Triggered by CK2....Pages 141-157
CK2: A Global Regulator of Cell Death....Pages 159-181
Protein Kinase CK2: Systematic Relationships with Other Posttranslational Modifications....Pages 183-196
Role for Protein Kinase CK2 on Cell Proliferation: Assessing CK2 Complex Components in the Nucleus During the Cell Cycle Progression....Pages 197-226
“Genuine” Casein Kinase: The False Sister of CK2 That Phosphorylates Secreted Proteins at S-x-E/pS Motifs....Pages 227-237
Front Matter....Pages 239-239
Dysregulated Expression of Protein Kinase CK2 in Renal Cancer....Pages 241-257
Protein Kinase CK2 and Dysregulated Oncogenic Inflammatory Signaling Pathways....Pages 259-280
CIGB-300: A Promising Anti-Casein Kinase 2 (CK2) Peptide for Cancer Targeted Therapy....Pages 281-298
Targeting CK2 for Cancer Therapy Using a Nanomedicine Approach....Pages 299-315
Front Matter....Pages 317-317
Screening of DTP Compound Libraries for CK2 Inhibitors with Focus on Natural Products....Pages 319-340
CK2 Inhibitors and the DYRK Family Protein Kinases....Pages 341-359
Sensitivity of Protein Kinase CK2 to ATP/GTP and Specific Inhibitors Depends on Complexity of Interacting Proteins....Pages 361-374
Back Matter....Pages 375-378
Front Matter....Pages i-xxiii
Front Matter....Pages 1-1
Yeast Asf1 Protein as Modulator of Protein Kinase CK2 Activity....Pages 3-16
Impressions from the Conformational and Configurational Space Captured by Protein Kinase CK2....Pages 17-33
Structural Basis of CK2 Regulation by Autoinhibitory Oligomerization....Pages 35-47
Maize RNA-Binding Protein ZmTGH: A New Partner for CK2β1 Regulatory Subunit....Pages 49-55
Front Matter....Pages 57-57
CK2 in Organ Development, Physiology, and Homeostasis....Pages 59-79
Protein Kinase CK2: A Window into the Posttranslational Regulation of the E(spl)/HES Repressors from Invertebrates and Vertebrates....Pages 81-107
Tissue-Specific Functions and Regulation of Protein Kinase CK2....Pages 109-123
CK2 Function in the Regulation of Akt Pathway....Pages 125-140
Cellular Zinc Signalling Is Triggered by CK2....Pages 141-157
CK2: A Global Regulator of Cell Death....Pages 159-181
Protein Kinase CK2: Systematic Relationships with Other Posttranslational Modifications....Pages 183-196
Role for Protein Kinase CK2 on Cell Proliferation: Assessing CK2 Complex Components in the Nucleus During the Cell Cycle Progression....Pages 197-226
“Genuine” Casein Kinase: The False Sister of CK2 That Phosphorylates Secreted Proteins at S-x-E/pS Motifs....Pages 227-237
Front Matter....Pages 239-239
Dysregulated Expression of Protein Kinase CK2 in Renal Cancer....Pages 241-257
Protein Kinase CK2 and Dysregulated Oncogenic Inflammatory Signaling Pathways....Pages 259-280
CIGB-300: A Promising Anti-Casein Kinase 2 (CK2) Peptide for Cancer Targeted Therapy....Pages 281-298
Targeting CK2 for Cancer Therapy Using a Nanomedicine Approach....Pages 299-315
Front Matter....Pages 317-317
Screening of DTP Compound Libraries for CK2 Inhibitors with Focus on Natural Products....Pages 319-340
CK2 Inhibitors and the DYRK Family Protein Kinases....Pages 341-359
Sensitivity of Protein Kinase CK2 to ATP/GTP and Specific Inhibitors Depends on Complexity of Interacting Proteins....Pages 361-374
Back Matter....Pages 375-378
![Protein Kinase CK2 Cellular Function in Normal and Disease States [1 ed.]
3319145436, 9783319145433](https://ebin.pub/img/200x200/protein-kinase-ck2-cellular-function-in-normal-and-disease-states-1nbsped-3319145436-9783319145433.jpg)
- Author / Uploaded
- Khalil Ahmed
- Olaf-Georg Issinger
- Ryszard Szyszka (eds.)
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