Lung Biology in Health and Disease Volume 185 Idiopathic Pulmonary Fibrosis [1 ed.] 9780824740733, 9780824758738, 0824740734
A discussion of the epidemiology, clinical features, and differential diagnoses of idiopathic pulmonary fibrosis (IPF).
244 65 1MB
English Pages 800 [803] Year 2003
Table of contents :
INTRODUCTION......Page 11
PREFACE......Page 13
CONTRIBUTORS......Page 15
CONTENTS......Page 21
Epidemiology of Idiopathic Pulmonary Fibrosis......Page 31
Genetics of Familial Pulmonary Fibrosis and Other Variants......Page 61
Clinical Features and Differential Diagnosis of Idiopathic Pulmonary Fibrosis......Page 85
Pathology of Usual Interstitial Pneumonia......Page 111
Nonspecific Interstitial Pneumonia......Page 131
Role of Physiological Assessment in Usual Interstitial Pneumonia......Page 167
Role of High-Resolution Thin Section Computed Tomographic Scanning......Page 197
Other Imaging Techniques for Idiopathic Interstitial Pneumonias......Page 267
Bronchoalveolar Lavage in Interstitial Lung Disease......Page 283
Pulmonary Fibrosis in Connective Tissue Disease......Page 303
Cytokine Phenotypes and the Progression of Chronic Pulmonary Fibrosis......Page 333
CXC Chemokines in Angiogenesis Related to Pulmonary Fibrosis......Page 351
Role of Polymorphonuclear Leukocytes in the Pathogenesis of Idiopathic Pulmonary Fibrosis......Page 371
Integrins and Pulmonary Fibrosis......Page 389
Oxidants and Antioxidants in Idiopathic Pulmonary Fibrosis......Page 409
Fibrin Turnover in Pulmonary Fibrosis......Page 427
Arachidonic Acid Metabolites: Potential Mediators and Therapeutic Targets in Fibrotic Lung Disease......Page 449
Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Pulmonary Fibrosis......Page 481
Extracellular Matrix......Page 511
Role of Fibroblasts and Myofibroblasts in Idiopathic Pulmonary Fibrosis......Page 537
Peptide and Provisional Matrix Signals in Idiopathic Pulmonary Fibrosis......Page 594
Role of Alveolar Type II Epithelial Cells in Pulmonary Fibrosis......Page 604
Surfactant Proteins in the Pathophysiology of Pulmonary Fibrosis......Page 640
Bronchiolar Epithelium in Idiopathic Pulmonary Fibrosis/Usual Interstitial Fibrosis......Page 662
Role of Viruses in the Pathogenesis of Pulmonary Fibrosis......Page 696
Current Treatment Options......Page 706
Future Directions in the Treatment of Idiopathic Pulmonary Fibrosis......Page 730
Future Directions in Genetic Strategies for Understanding and Treating Idiopathic Pulmonary Fibrosis......Page 764
INDEX......Page 792
INTRODUCTION......Page 11
PREFACE......Page 13
CONTRIBUTORS......Page 15
CONTENTS......Page 21
Epidemiology of Idiopathic Pulmonary Fibrosis......Page 31
Genetics of Familial Pulmonary Fibrosis and Other Variants......Page 61
Clinical Features and Differential Diagnosis of Idiopathic Pulmonary Fibrosis......Page 85
Pathology of Usual Interstitial Pneumonia......Page 111
Nonspecific Interstitial Pneumonia......Page 131
Role of Physiological Assessment in Usual Interstitial Pneumonia......Page 167
Role of High-Resolution Thin Section Computed Tomographic Scanning......Page 197
Other Imaging Techniques for Idiopathic Interstitial Pneumonias......Page 267
Bronchoalveolar Lavage in Interstitial Lung Disease......Page 283
Pulmonary Fibrosis in Connective Tissue Disease......Page 303
Cytokine Phenotypes and the Progression of Chronic Pulmonary Fibrosis......Page 333
CXC Chemokines in Angiogenesis Related to Pulmonary Fibrosis......Page 351
Role of Polymorphonuclear Leukocytes in the Pathogenesis of Idiopathic Pulmonary Fibrosis......Page 371
Integrins and Pulmonary Fibrosis......Page 389
Oxidants and Antioxidants in Idiopathic Pulmonary Fibrosis......Page 409
Fibrin Turnover in Pulmonary Fibrosis......Page 427
Arachidonic Acid Metabolites: Potential Mediators and Therapeutic Targets in Fibrotic Lung Disease......Page 449
Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Pulmonary Fibrosis......Page 481
Extracellular Matrix......Page 511
Role of Fibroblasts and Myofibroblasts in Idiopathic Pulmonary Fibrosis......Page 537
Peptide and Provisional Matrix Signals in Idiopathic Pulmonary Fibrosis......Page 594
Role of Alveolar Type II Epithelial Cells in Pulmonary Fibrosis......Page 604
Surfactant Proteins in the Pathophysiology of Pulmonary Fibrosis......Page 640
Bronchiolar Epithelium in Idiopathic Pulmonary Fibrosis/Usual Interstitial Fibrosis......Page 662
Role of Viruses in the Pathogenesis of Pulmonary Fibrosis......Page 696
Current Treatment Options......Page 706
Future Directions in the Treatment of Idiopathic Pulmonary Fibrosis......Page 730
Future Directions in Genetic Strategies for Understanding and Treating Idiopathic Pulmonary Fibrosis......Page 764
INDEX......Page 792
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