Electrospray and MALDI mass spectrometry: fundamentals, instrumentation, practicalities, and biological applications [2 ed.] 9780471741077, 0471741078, 9781118211557, 1118211553

Discover how advances in mass spectrometry are fueling new discoveries across a broad range of research areasElectrospra

248 86 18MB

English Pages 847 Year 2010;2013

Table of contents :
""Title Page""
""Copyright""
""Foreword: Desorption Ionization and Spray Ionization: Connections and Progress""
""FORCES DRIVING THE DEVELOPMENT OF IONIZATION METHODS""
""SPRAY IONIZATION AND DESORPTION IONIZATION""
""AMBIENT IONIZATION""
""MOLECULAR IMAGING""
""ENHANCED ANALYSIS""
""FUNDAMENTAL SCIENCE""
""OPPORTUNITIES AND UNSOLVED PROBLEMS""
""REFERENCES""
""Foreword to the First Edition""
""Preface""
""Contributors""
""Part I: Fundamentals of ES""
""Chapter 1: On the Mechanism of Electrospray Ionization Mass Spectrometry (ESIMS)""
""1.1 INTRODUCTION"" ""1.2 PRODUCTION OF GAS-PHASE IONS BY ELECTROSPRAY AND ELECTROSPRAY IONIZATION MASS SPECTROMETRY""""REFERENCES""
""Chapter 2: Selectivity in Electrospray Ionization Mass Spectrometry""
""2.1 INTRODUCTION""
""2.2 MECHANISMS OF ION FORMATION""
""2.3 IONIC COMPOSITION OF ESI DROPLETS""
""2.4 EXCESS CHARGE AND ITS LOCATION""
""2.5 A MODEL FOR COMPETITION AND SATURATION IN SOLUTION""
""2.6 SURFACE ACTIVITY AS A SOURCE OF SELECTIVITY""
""2.7 COMPETITION AND SIGNAL SUPPRESSION""
""2.8 GAS-PHASE PROTON TRANSFER AS A SOURCE OF SELECTIVITY""
""2.9 EFFECTS OF NEBULIZATION AND FLOW RATE"" ""2.10 DIFFERENCES BETWEEN POSITIVE AND NEGATIVE ION ESI-MS""""REFERENCES""
""Chapter 3: Electrochemistry of the Electrospray Ion Source""
""3.1 INTRODUCTION""
""3.2 ELECTROCHEMICAL BASICS OF THE MOST COMMON ELECTROSPRAY SYSTEMS""
""3.3 ALTERNATIVE EMITTER ELECTRODE CONFIGURATIONS""
""3.4 ANALYTICAL IMPLICATIONS AND BENEFITS""
""3.5 SUMMARY""
""ACKNOWLEDGMENTS""
""REFERENCES""
""Chapter 4: ESI Source Design""
""4.1 ELECTROSPRAY NEBULIZATION""
""4.2 ELECTROSPRAY CONSTRUCTION AND OPERATION""
""4.3 ATMOSPHERIC PRESSURE IONIZATION SOURCE CONSTRUCTION"" ""4.4 UP-FRONT COLLISION-INDUCED DISSOCIATION""""4.5 MASS SCALE CALIBRATION""
""REFERENCES""
""Part II: Fundamentals of MALDI""
""Chapter 5: MALDI Ionization Mechanisms: an Overview""
""5.1 INTRODUCTION""
""5.2 THE TWO-STEP FRAMEWORK AND PRIMARY VERSUS SECONDARY MECHANISMS""
""5.3 PRIMARY IONIZATION MECHANISMS""
""5.4 SECONDARY IONIZATION PROCESSES""
""5.5 SURFACE EFFECTS""
""5.6 CONCLUSIONS""
""REFERENCES""
""Chapter 6: The Development of Matrix-Assisted Laser Desorption/Ionization Sources""
""6.1 INTRODUCTION""
""6.2 LASER DESORPTION ANALYZERS"" ""6.3 LASER MICROPROBE FOR MASS ANALYSIS""""6.4 MATRIX-ASSISTED LASER DESORPTION""
""6.5 COUPLING CHROMATOGRAPHIC SEPARATION TO LDI""
""6.6 MALDI FROM VARIOUS SURFACES""
""6.7 MALDI AT ELEVATED PRESSURES""
""REFERENCES""
""Chapter 7: A Comparison of MALDI Matrices""
""7.1 INTRODUCTION""
""7.2 MALDI MATRIX PROPERTIES AND PREPARATIONS""
""7.3 MATRIX CLASSES""
""7.4 NONTRADITIONAL MATRICES""
""7.5 HOT VERSUS COLD MATRICES""
""REFERENCES""
""Chapter 8: MALDI Imaging Mass Spectrometry""
""8.1 INTRODUCTION""
""8.2 MALDI PROFILING VERSUS MALDI IMAGING""
""8.3 SAMPLE PREPARATION""

Electrospray and MALDI mass spectrometry: fundamentals, instrumentation, practicalities, and biological applications [2 ed.]
9780471741077, 0471741078, 9781118211557, 1118211553

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