Electrospray and MALDI mass spectrometry: fundamentals, instrumentation, practicalities, and biological applications [2 ed.] 9780471741077, 0471741078, 9781118211557, 1118211553

Discover how advances in mass spectrometry are fueling new discoveries across a broad range of research areasElectrospra

251 86 18MB

English Pages 847 Year 2010;2013

Table of contents :
""Title Page""
""Copyright""
""Foreword: Desorption Ionization and Spray Ionization: Connections and Progress""
""FORCES DRIVING THE DEVELOPMENT OF IONIZATION METHODS""
""SPRAY IONIZATION AND DESORPTION IONIZATION""
""AMBIENT IONIZATION""
""MOLECULAR IMAGING""
""ENHANCED ANALYSIS""
""FUNDAMENTAL SCIENCE""
""OPPORTUNITIES AND UNSOLVED PROBLEMS""
""REFERENCES""
""Foreword to the First Edition""
""Preface""
""Contributors""
""Part I: Fundamentals of ES""
""Chapter 1: On the Mechanism of Electrospray Ionization Mass Spectrometry (ESIMS)""
""1.1 INTRODUCTION"" ""1.2 PRODUCTION OF GAS-PHASE IONS BY ELECTROSPRAY AND ELECTROSPRAY IONIZATION MASS SPECTROMETRY""""REFERENCES""
""Chapter 2: Selectivity in Electrospray Ionization Mass Spectrometry""
""2.1 INTRODUCTION""
""2.2 MECHANISMS OF ION FORMATION""
""2.3 IONIC COMPOSITION OF ESI DROPLETS""
""2.4 EXCESS CHARGE AND ITS LOCATION""
""2.5 A MODEL FOR COMPETITION AND SATURATION IN SOLUTION""
""2.6 SURFACE ACTIVITY AS A SOURCE OF SELECTIVITY""
""2.7 COMPETITION AND SIGNAL SUPPRESSION""
""2.8 GAS-PHASE PROTON TRANSFER AS A SOURCE OF SELECTIVITY""
""2.9 EFFECTS OF NEBULIZATION AND FLOW RATE"" ""2.10 DIFFERENCES BETWEEN POSITIVE AND NEGATIVE ION ESI-MS""""REFERENCES""
""Chapter 3: Electrochemistry of the Electrospray Ion Source""
""3.1 INTRODUCTION""
""3.2 ELECTROCHEMICAL BASICS OF THE MOST COMMON ELECTROSPRAY SYSTEMS""
""3.3 ALTERNATIVE EMITTER ELECTRODE CONFIGURATIONS""
""3.4 ANALYTICAL IMPLICATIONS AND BENEFITS""
""3.5 SUMMARY""
""ACKNOWLEDGMENTS""
""REFERENCES""
""Chapter 4: ESI Source Design""
""4.1 ELECTROSPRAY NEBULIZATION""
""4.2 ELECTROSPRAY CONSTRUCTION AND OPERATION""
""4.3 ATMOSPHERIC PRESSURE IONIZATION SOURCE CONSTRUCTION"" ""4.4 UP-FRONT COLLISION-INDUCED DISSOCIATION""""4.5 MASS SCALE CALIBRATION""
""REFERENCES""
""Part II: Fundamentals of MALDI""
""Chapter 5: MALDI Ionization Mechanisms: an Overview""
""5.1 INTRODUCTION""
""5.2 THE TWO-STEP FRAMEWORK AND PRIMARY VERSUS SECONDARY MECHANISMS""
""5.3 PRIMARY IONIZATION MECHANISMS""
""5.4 SECONDARY IONIZATION PROCESSES""
""5.5 SURFACE EFFECTS""
""5.6 CONCLUSIONS""
""REFERENCES""
""Chapter 6: The Development of Matrix-Assisted Laser Desorption/Ionization Sources""
""6.1 INTRODUCTION""
""6.2 LASER DESORPTION ANALYZERS"" ""6.3 LASER MICROPROBE FOR MASS ANALYSIS""""6.4 MATRIX-ASSISTED LASER DESORPTION""
""6.5 COUPLING CHROMATOGRAPHIC SEPARATION TO LDI""
""6.6 MALDI FROM VARIOUS SURFACES""
""6.7 MALDI AT ELEVATED PRESSURES""
""REFERENCES""
""Chapter 7: A Comparison of MALDI Matrices""
""7.1 INTRODUCTION""
""7.2 MALDI MATRIX PROPERTIES AND PREPARATIONS""
""7.3 MATRIX CLASSES""
""7.4 NONTRADITIONAL MATRICES""
""7.5 HOT VERSUS COLD MATRICES""
""REFERENCES""
""Chapter 8: MALDI Imaging Mass Spectrometry""
""8.1 INTRODUCTION""
""8.2 MALDI PROFILING VERSUS MALDI IMAGING""
""8.3 SAMPLE PREPARATION""

Electrospray and MALDI mass spectrometry: fundamentals, instrumentation, practicalities, and biological applications [2 ed.]
9780471741077, 0471741078, 9781118211557, 1118211553

Author / Uploaded
Cole
Richard B(Editor)

0 0 0
Like this paper and download? You can publish your own PDF file online for free in a few minutes! Sign Up

Recommend Papers

Electrospray and MALDI mass spectrometry: fundamentals, instrumentation, practicalities, and biological applications [2 ed.] 9780471741077, 4420105720, 0471741078, 9781118211557, 1118211553

Discover how advances in mass spectrometry are fueling new discoveries across a broad range of research areasElectrospra

323 54 28MB Read more

Electrospray and MALDI Mass Spectrometry: Fundamentals, Instrumentation, Practicalities, and Biological Applications [2 ed.] 0471741078, 9780471741077, 0470588896, 9780470588895

Discover how advances in mass spectrometry are fueling new discoveries across a broad range of research areasElectrospra

333 34 16MB Read more

Mass spectrometry: instrumentation, interpretation, and applications 0471713953, 9780471713951, 9780470395806

With contributions from noted experts from Europe and North America, Mass Spectrometry Instrumentation, Interpretation,

498 97 10MB Read more

Mass Spectrometry - Instrumentation, Interpretation, and Applications 9780471713951, 0471713953

With contributions from noted experts from Europe and North America, Mass Spectrometry Instrumentation, Interpretation,

410 174 10MB Read more

Microbiological Identification using MALDI-TOF and Tandem Mass Spectrometry: Industrial and Environmental Applications 1119814057, 9781119814054

Microbiological Identification using MALDI-TOF and Tandem Mass Spectrometry Detailed resource presenting the capabilitie

190 45 37MB Read more

Time-of-Flight Mass Spectrometry: Instrumentation and Applications in Biological Research (Acs Professional Reference Book) [1 ed.] 0841234744, 9780841234741

This book presents the basic principles of time-of-flight (TOF) mass spectrometry with a strong emphasis on applications

352 105 10KB Read more

Ion mobility spectrometry-mass spectrometry : theory and applications 9781439813249, 1439813248

451 16 8MB Read more

Cluster Secondary Ion Mass Spectrometry: Principles and Applications

Wiley, 2013. — 358 p.Explores the impact of the latest breakthroughs in cluster SIMS technology Cluster secondary ion ma

416 46 2MB Read more

Mass Spectrometry for Lipidomics. Methods and Applications [Volume 1] 9783527352210

180 32 16MB Read more

Mass Spectrometry: Principles and Applications [3 ed.] 047003310X, 9780470033104

The latest edition of a highly successful textbook, Mass Spectrometry, Third Edition provides students with a complete o

936 37 5MB Read more