Table of contents : Title Page Copyright Page Book Series Table of Contents Detailed Table of Contents Preface Acknowledgment Chapter 1: Drug Discovery Chapter 2: Chemical Structure Databases in Drug Discovery Chapter 3: Lead Optimization in the Drug Discovery Process Chapter 4: QSAR and Lead Optimization Chapter 5: Virtual Screening and Its Applications in Drug Discovery Process Chapter 6: Computational Investigation of Versatile Activity of Piperine Chapter 7: Target Identification of HDAC8 Isoform for the Treatment of Cancer Chapter 8: Molecular Modelling Studies of Novel COX-2 Inhibitors Chapter 9: Construction and Analysis of Protein-Protein Interaction Network Chapter 10: Quality by Design in Pharmaceutical Formulation Chapter 11: The Next Generation Sequencing Techniques and Application in Drug Discovery and Development Chapter 12: Semantic Technologies for Medical Knowledge Representation Compilation of References About the Contributors Index