Advances in Host-Directed Therapies Against Tuberculosis [1st ed.] 9783030569044, 9783030569051

Table of contents :
Front Matter ....Pages i-xiii
Front Matter ....Pages 1-1
Introduction: An Overview of Host-Directed Therapies for Tuberculosis (Daniel J. Frank, Robert N. Mahon)....Pages 3-12
Front Matter ....Pages 13-13
Sirtuin Deacetylases: Linking Mycobacterial Infection and Host Metabolism (Lorissa Smulan, Hardy Kornfeld, Amit Singhal)....Pages 15-26
The Mammalian Target of Rapamycin Complex 1 (mTORC1): An Ally of M. tuberculosis in Host Cells (Natalie Bruiners, Valentina Guerrini, Maria Laura Gennaro)....Pages 27-40
HIF-1α as a Potential Therapeutic Target for Tuberculosis Treatment (Qingkui Jiang, Maria Laura Gennaro, Lanbo Shi)....Pages 41-59
Nuclear Receptors in Host-Directed Therapies against Tuberculosis (Eun-Kyeong Jo)....Pages 61-67
Front Matter ....Pages 69-69
Autophagy as a Target for Host-Directed Therapy Against Tuberculosis (Surbhi Verma, Raman Deep Sharma, Dhiraj Kumar)....Pages 71-95
Metformin: A Leading HDT Candidate for TB (Amit Singhal, Hardy Kornfeld)....Pages 97-108
Statins as Host-Directed Therapy for Tuberculosis (Noton K. Dutta, Petros C. Karakousis)....Pages 109-119
Antimycobacterial Attributes of Mitochondria: An Insight into Host Defense Mechanisms (Rikesh K. Dubey, Apoorva Narain)....Pages 121-129
Front Matter ....Pages 131-131
Conventional and Unconventional Lymphocytes in Immunity Against Mycobacterium tuberculosis (Paula Ruibal, Tom H. M. Ottenhoff, Simone A. Joosten)....Pages 133-168
Targeting Inhibitory Cells Such as Tregs and MDSCs in the Tuberculous Granuloma (Sadiya Parveen, John R. Murphy, William R. Bishai)....Pages 169-203
Targeting Suppressor T Cells (Léanie Kleynhans, Gerhard Walzl)....Pages 205-210
Neutrophil-Mediated Mechanisms as Targets for Host-Directed Therapies Against Tuberculosis (Tobias K. Dallenga, Ulrich E. Schaible)....Pages 211-217
Type I Interferon and Interleukin-1 Driven Inflammatory Pathways as Targets for HDT in Tuberculosis (Katrin D. Mayer-Barber, Christopher M. Sassetti)....Pages 219-232
H. Mucosal-Associated Invariant and Vγ9Vδ2 T Cells (Charles Kyriakos Vorkas, Michael Stephen Glickman)....Pages 233-245
Alveolar Epithelial Cells (Angélica M. Olmo-Fontánez, Jordi B. Torrelles)....Pages 247-255
Front Matter ....Pages 257-257
In Vitro Models of Human Granuloma Formation to Analyze Host-Directed Therapies (Liku B. Tezera, Michaela T. Reichmann, Basim Al Shammari, Paul T. Elkington)....Pages 259-265
C3HeB/FeJ as a Key Mouse Strain for Testing Host-Directed Therapies Against Tuberculosis (Pere-Joan Cardona, Cristina Vilaplana)....Pages 267-273
The Rabbit Model for Assessing Host-Directed Therapies for Tuberculosis (Selvakumar Subbian, Gilla Kaplan)....Pages 275-282
Front Matter ....Pages 283-283
Clinical Trials of TB-HDT Candidates (Robert S. Wallis)....Pages 285-293
Outcomes for Clinical Trials of Host-Directed Therapies for Tuberculosis (Akshay N. Gupte, Sara C. Auld, William N. Checkley, Gregory P. Bisson)....Pages 295-310
Pharmacological Considerations for Clinical Trials of Host-Directed Therapies for Tuberculosis (Elisa H. Ignatius, Kelly E. Dooley)....Pages 311-332